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Assembly of plasmid DNA with pyrene-amines cationic amphiphiles into nanoparticles and their visible lysosome localization
其他题名Assembly of plasmid DNA with pyrene-amines cationic amphiphiles into nanoparticles and their visible lysosome localization
Sheng RL(盛瑞隆)1; AN FEIFEI1; Wang Z(王昭)1; LI MINGRUI1; Cao AM(曹阿民)1
2015
发表期刊RSC Adv.
卷号5期号:16页码:12338-12345
摘要In this study, we constructed a visible model for drug/gene dual delivery. Firstly, we prepared a series of pyrene fluorophore bearing cationic amphiphiles (Py-amines), which could be further employed as amphiphilic gene carriers and antitumor polyamine drug models. Then, the Py-amines fluorescent amphiphiles were utilized to bind/load plasmid DNA via electrostatic interactions to form nano-sized particles in aqueous solution. The average size, zeta potential and morphology of the self-assembled Pyamines/ pDNA complexes were found to be largely dependent on the molecular structures of Py-amines amphiphiles. Moreover, the Py-amines and their pDNA complexes showed an evident cell proliferation inhibition capability in H1299 (human lung cancer) cells. Notably, the lysosomal localization of the Pyamines/ pDNA complexes could be directly visualized using fluorescence microscopy in vitro. In summary, this current study could provide new and visible approach to design polyamine-based antitumor drug/plasmid DNA dual delivery systems, which could facilitate a greater understanding of the intracellular trafficking/localization of polyamine-based cationic gene/drug payloads.
文章类型论文
学科领域高分子化学
DOI10.1039/c4ra06879c
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000348985400081
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39837
专题高分子材料研究室
通讯作者Sheng RL(盛瑞隆); Cao AM(曹阿民)
作者单位1.中科院上海有机化学研究所, 有机功能分子合成与组装化学重点实验室
2.国家纳米科学中心
推荐引用方式
GB/T 7714
Sheng RL,AN FEIFEI,Wang Z,et al. Assembly of plasmid DNA with pyrene-amines cationic amphiphiles into nanoparticles and their visible lysosome localization[J]. RSC Adv.,2015,5(16):12338-12345.
APA 盛瑞隆,AN FEIFEI,王昭,LI MINGRUI,&曹阿民.(2015).Assembly of plasmid DNA with pyrene-amines cationic amphiphiles into nanoparticles and their visible lysosome localization.RSC Adv.,5(16),12338-12345.
MLA 盛瑞隆,et al."Assembly of plasmid DNA with pyrene-amines cationic amphiphiles into nanoparticles and their visible lysosome localization".RSC Adv. 5.16(2015):12338-12345.
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