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学科主题: 高分子化学
题名: Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
其他题名: Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
作者: Xu ZY(徐志远)1; Zhu SJ(朱绍佳)1; Wang MW(王明伟)1; Li YJ(李永军)1; Shi P(史萍)1; Huang XY(黄晓宇)1
通讯作者: 史萍 ; 黄晓宇
刊名: ACS Appl. Mater. Interfaces
发表日期: 2015
DOI: 10.1021/am507798d
卷: 7, 期:2, 页:1355-1363
收录类别: SCI
文章类型: 论文
英文摘要: Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000348332700039
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39835
Appears in Collections:高分子材料研究室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 有机功能分子合成与组装化学重点实验室
2.华东理工大学
3.复旦大学肿瘤医院

Recommended Citation:
Xu ZY,Zhu SJ,Wang MW,et al. Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier[J]. ACS Appl. Mater. Interfaces,2015,7(2):1355-1363.
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