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Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
Alternative TitleDelivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
Xu ZY(徐志远)1; Zhu SJ(朱绍佳)1; Wang MW(王明伟)1; Li YJ(李永军)1; Shi P(史萍)1; Huang XY(黄晓宇)1
Source PublicationACS Appl. Mater. Interfaces
AbstractPaclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
Subject Area高分子化学
Indexed BySCI
WOS IDWOS:000348332700039
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorShi P(史萍); Huang XY(黄晓宇)
Affiliation1.中科院上海有机化学研究所, 有机功能分子合成与组装化学重点实验室
Recommended Citation
GB/T 7714
Xu ZY,Zhu SJ,Wang MW,et al. Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier[J]. ACS Appl. Mater. Interfaces,2015,7(2):1355-1363.
APA 徐志远,朱绍佳,王明伟,李永军,史萍,&黄晓宇.(2015).Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier.ACS Appl. Mater. Interfaces,7(2),1355-1363.
MLA 徐志远,et al."Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier".ACS Appl. Mater. Interfaces 7.2(2015):1355-1363.
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