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Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
其他题名Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
Xu ZY(徐志远)1; Zhu SJ(朱绍佳)1; Wang MW(王明伟)1; Li YJ(李永军)1; Shi P(史萍)1; Huang XY(黄晓宇)1
2015
发表期刊ACS Appl. Mater. Interfaces
卷号7期号:2页码:1355-1363
摘要Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
文章类型论文
学科领域高分子化学
DOI10.1021/am507798d
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000348332700039
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39835
专题高分子材料研究室
通讯作者Shi P(史萍); Huang XY(黄晓宇)
作者单位1.中科院上海有机化学研究所, 有机功能分子合成与组装化学重点实验室
2.华东理工大学
3.复旦大学肿瘤医院
推荐引用方式
GB/T 7714
Xu ZY,Zhu SJ,Wang MW,et al. Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier[J]. ACS Appl. Mater. Interfaces,2015,7(2):1355-1363.
APA 徐志远,朱绍佳,王明伟,李永军,史萍,&黄晓宇.(2015).Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier.ACS Appl. Mater. Interfaces,7(2),1355-1363.
MLA 徐志远,et al."Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier".ACS Appl. Mater. Interfaces 7.2(2015):1355-1363.
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