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Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
其他题名Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
Hou XD(侯小东); Zhang T(张涛); Cao AM(曹阿民)
2015
发表期刊J. Biomed. Mater. Res. Part B
卷号103期号:1页码:52-61
摘要In the present work, new amphiphilic macroporous polymeric adsorbent (AMPA) membranes for LDL-apheresis were prepared by Co-60 -ray irradiation-induced grafting copolymerization of polypropylene (PP) nonwoven fabric with acrylic acid, followed by bonding cholesterol through linkers of different length. The new AMPA membranes were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscope (SEM), and contact angle microscopy. Static adsorption and hemo-perfusion tests show these new adsorbents could efficiently remove LDL from human plasma. Meanwhile, the AMPA displayed good adsorption capacity for triglyceride (TG) as well. The static adsorption performance of the AMPA membranes depends on the length of linker. In addition, a balance between the amount of bonded cholesterol and remaining carboxyl group was found necessary to reach the optimal adsorption performance. The best result was achieved by the AMPA membrane PA(15)C(6)-3, by which 62.8 +/- 3.8 g of LDL-C, 16.5 +/- 0.71 g of HDL-C, 132.4 +/- 3.0 g of TG are removed from human plasma per square centimeter. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 52-61, 2015.
文章类型论文
学科领域高分子化学
DOI10.1002/jbm.b.33190
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000346191600007
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39831
专题高分子材料研究室
通讯作者Hou XD(侯小东); Cao AM(曹阿民)
作者单位中科院上海有机化学研究所, 高分子材料研究室
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Hou XD,Zhang T,Cao AM. Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma[J]. J. Biomed. Mater. Res. Part B,2015,103(1):52-61.
APA 侯小东,张涛,&曹阿民.(2015).Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma.J. Biomed. Mater. Res. Part B,103(1),52-61.
MLA 侯小东,et al."Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma".J. Biomed. Mater. Res. Part B 103.1(2015):52-61.
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