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学科主题: 高分子化学
题名: Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
其他题名: Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
作者: Hou XD(侯小东); Zhang T(张涛); Cao AM(曹阿民)
通讯作者: 侯小东 ; 曹阿民
刊名: J. Biomed. Mater. Res. Part B
发表日期: 2015
DOI: 10.1002/jbm.b.33190
卷: 103, 期:1, 页:52-61
收录类别: SCI
文章类型: 论文
英文摘要: In the present work, new amphiphilic macroporous polymeric adsorbent (AMPA) membranes for LDL-apheresis were prepared by Co-60 -ray irradiation-induced grafting copolymerization of polypropylene (PP) nonwoven fabric with acrylic acid, followed by bonding cholesterol through linkers of different length. The new AMPA membranes were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscope (SEM), and contact angle microscopy. Static adsorption and hemo-perfusion tests show these new adsorbents could efficiently remove LDL from human plasma. Meanwhile, the AMPA displayed good adsorption capacity for triglyceride (TG) as well. The static adsorption performance of the AMPA membranes depends on the length of linker. In addition, a balance between the amount of bonded cholesterol and remaining carboxyl group was found necessary to reach the optimal adsorption performance. The best result was achieved by the AMPA membrane PA(15)C(6)-3, by which 62.8 +/- 3.8 g of LDL-C, 16.5 +/- 0.71 g of HDL-C, 132.4 +/- 3.0 g of TG are removed from human plasma per square centimeter. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 52-61, 2015.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000346191600007
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39831
Appears in Collections:高分子材料研究室_期刊论文

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作者单位: 中科院上海有机化学研究所, 高分子材料研究室

Recommended Citation:
Hou XD,Zhang T,Cao AM. Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma[J]. J. Biomed. Mater. Res. Part B,2015,103(1):52-61.
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