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Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
Alternative TitlePreparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma
Hou XD(侯小东); Zhang T(张涛); Cao AM(曹阿民)
2015
Source PublicationJ. Biomed. Mater. Res. Part B
Volume103Issue:1Pages:52-61
AbstractIn the present work, new amphiphilic macroporous polymeric adsorbent (AMPA) membranes for LDL-apheresis were prepared by Co-60 -ray irradiation-induced grafting copolymerization of polypropylene (PP) nonwoven fabric with acrylic acid, followed by bonding cholesterol through linkers of different length. The new AMPA membranes were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscope (SEM), and contact angle microscopy. Static adsorption and hemo-perfusion tests show these new adsorbents could efficiently remove LDL from human plasma. Meanwhile, the AMPA displayed good adsorption capacity for triglyceride (TG) as well. The static adsorption performance of the AMPA membranes depends on the length of linker. In addition, a balance between the amount of bonded cholesterol and remaining carboxyl group was found necessary to reach the optimal adsorption performance. The best result was achieved by the AMPA membrane PA(15)C(6)-3, by which 62.8 +/- 3.8 g of LDL-C, 16.5 +/- 0.71 g of HDL-C, 132.4 +/- 3.0 g of TG are removed from human plasma per square centimeter. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 52-61, 2015.
Subtype论文
Subject Area高分子化学
DOI10.1002/jbm.b.33190
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000346191600007
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39831
Collection高分子材料研究室
Corresponding AuthorHou XD(侯小东); Cao AM(曹阿民)
Affiliation中科院上海有机化学研究所, 高分子材料研究室
Recommended Citation
GB/T 7714
Hou XD,Zhang T,Cao AM. Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma[J]. J. Biomed. Mater. Res. Part B,2015,103(1):52-61.
APA 侯小东,张涛,&曹阿民.(2015).Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma.J. Biomed. Mater. Res. Part B,103(1),52-61.
MLA 侯小东,et al."Preparation of new amphiphilic macroporous nonwoven polymeric adsorbents aimed for selective removal of low-density lipoprotein from plasma".J. Biomed. Mater. Res. Part B 103.1(2015):52-61.
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