中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 计算机化学与化学信息学研究室  > 期刊论文
学科主题: 计算机化学
题名: Efficient synthesis of baicalin and its analogs
其他题名: 黄芩苷和其类似物的高效合成法
作者: Li YF(李杨峰)1; Yu B(俞飚)1; Sun JS(孙建松)1; Wang RX(王任小)1
通讯作者: 孙建松 ; 王任小
刊名: Tetrahedron Lett.
发表日期: 2015
DOI: 10.1016/j.tetlet.2015.04.083
卷: 56, 期:24, 页:3816-3819
收录类别: SCI
文章类型: 论文
英文摘要: Baicalin is the most abundant ingredient of Scutellaria baicalensis, which has been shown to have a variety of biological activities. In this study, we have developed an efficient synthetic route for this compound based on Koenigs-Knorr glycosylation and mild-basic deprotection. Through this route, baicalin was obtained from cheap starting materials in a linear longest 10-step sequence with an overall yield of 27%. Four analogs of baicalin were also synthesized in high yields with the key protocols developed in the synthesis of baicalin, demonstrating the general applicability of our synthetic route. Efficient synthesis of baicalin and its analogs will hopefully facilitate further structure-activity relationship studies of this class of compounds. (C) 2015 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000356554900024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39822
Appears in Collections:计算机化学与化学信息学研究室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2015316.pdf(670KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.江西师范大学
3.澳门科技大学

Recommended Citation:
Li YF,Yu B,Sun JS,et al. Efficient synthesis of baicalin and its analogs[J]. Tetrahedron Lett.,2015,56(24):3816-3819.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[李杨峰]'s Articles
[俞飚]'s Articles
[孙建松]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[李杨峰]‘s Articles
[俞飚]‘s Articles
[孙建松]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2015316.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace