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Efficient synthesis of baicalin and its analogs
Alternative Title黄芩苷和其类似物的高效合成法
Li YF(李杨峰)1; Yu B(俞飚)1; Sun JS(孙建松)1; Wang RX(王任小)1
Source PublicationTetrahedron Lett.
AbstractBaicalin is the most abundant ingredient of Scutellaria baicalensis, which has been shown to have a variety of biological activities. In this study, we have developed an efficient synthetic route for this compound based on Koenigs-Knorr glycosylation and mild-basic deprotection. Through this route, baicalin was obtained from cheap starting materials in a linear longest 10-step sequence with an overall yield of 27%. Four analogs of baicalin were also synthesized in high yields with the key protocols developed in the synthesis of baicalin, demonstrating the general applicability of our synthetic route. Efficient synthesis of baicalin and its analogs will hopefully facilitate further structure-activity relationship studies of this class of compounds. (C) 2015 Elsevier Ltd. All rights reserved.
Subject Area计算机化学
Indexed BySCI
WOS IDWOS:000356554900024
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorSun JS(孙建松); Wang RX(王任小)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Li YF,Yu B,Sun JS,et al. Efficient synthesis of baicalin and its analogs[J]. Tetrahedron Lett.,2015,56(24):3816-3819.
APA 李杨峰,俞飚,孙建松,&王任小.(2015).Efficient synthesis of baicalin and its analogs.Tetrahedron Lett.,56(24),3816-3819.
MLA 李杨峰,et al."Efficient synthesis of baicalin and its analogs".Tetrahedron Lett. 56.24(2015):3816-3819.
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