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学科主题: 天然产物有机化学
题名: Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine
其他题名: 亚硝基-烯氢反应构建1-氮杂螺环[4.4]壬烷以及其在(±)-三尖杉碱模型反应中的应用
作者: Huang SH(黄莎华)1; Tian XC(田学超)1; Mi XW(米贤伟)1; Wang Y(王燕)1; Hong R(洪然)1
通讯作者: 黄莎华 ; 王燕
刊名: Tetrahedron Lett.
发表日期: 2015
DOI: 10.1016/j.tetlet.2015.10.002
卷: 56, 期:48, 页:6656-6658
收录类别: SCI
文章类型: 论文
英文摘要: In this communication, a nitroso-ene cyclization was devised to rapidly construct 1-azaspiro[4.4]nonane, a key structural motif which was further implemented into the modular synthesis of (+/-)-cephalotaxine (6). The whole synthesis route to access the key intermediate 7 involves eight steps from a commercially available 1,2-epoxycyclopentane (12) and five purifications on silica gel column. The direct nitroso-ene reaction to 1-azabicyclo[4.4]non-2-one paves a way to a future development of the practical synthesis of cephalotaxus alkaloids. (C) 2015 Published by Elsevier Ltd.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000365060400002
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39813
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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作者单位: 1.上海应用技术学院
2.中科院上海有机化学研究所, 天然产物有机合成化学重点实验室

Recommended Citation:
Huang SH,Tian XC,Mi XW,et al. Nitroso-ene cyclization enabled access to 1-azaspiro[4.4]nonane and its application in a modular synthesis toward (+/-)-cephalotaxine[J]. Tetrahedron Lett.,2015,56(48):6656-6658.
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