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学科主题: 天然产物有机化学
题名: Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites
其他题名: 螺酰胺催化的通过形成具有的活化位点的酮亚胺中间体构建高对映选择性的螺环羟吲哚
作者: Sun QS(孙强盛)1; Zhu H(朱华)1; Chen YJ(陈永剑)1; Yang XD(杨笑迪)1; Sun XW(孙兴文)1; Lin GQ(林国强)1
通讯作者: 孙兴文
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201506206
卷: 54, 期:45, 页:13253-13257
收录类别: SCI
文章类型: 论文
英文摘要: A new method for the construction of five-membered spirocyclic oxindoles is based on a Michael-Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine-derived squaramide. The desired products were obtained in excellent yields (up to 94%) and stereoselectivities (up to >20:1 d.r., >99% ee). A scaled-up variant also proceeded smoothly showing that the one-pot reaction might find application in the synthesis of bioactive-compound libraries.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000363691500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39807
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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作者单位: 1.复旦大学
2.中科院上海有机化学研究所

Recommended Citation:
Sun QS,Zhu H,Chen YJ,et al. Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites[J]. Angew. Chem.-Int. Edit.,2015,54(45):13253-13257.
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