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Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites
Alternative Title螺酰胺催化的通过形成具有的活化位点的酮亚胺中间体构建高对映选择性的螺环羟吲哚
Sun QS(孙强盛)1; Zhu H(朱华)1; Chen YJ(陈永剑)1; Yang XD(杨笑迪)1; Sun XW(孙兴文)1; Lin GQ(林国强)1
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:45Pages:13253-13257
AbstractA new method for the construction of five-membered spirocyclic oxindoles is based on a Michael-Mannich cascade reaction of a ketimine intermediated catalyzed by a bifunctional quinine-derived squaramide. The desired products were obtained in excellent yields (up to 94%) and stereoselectivities (up to >20:1 d.r., >99% ee). A scaled-up variant also proceeded smoothly showing that the one-pot reaction might find application in the synthesis of bioactive-compound libraries.
Subtype论文
Subject Area天然产物有机化学
DOI10.1002/anie.201506206
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000363691500015
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39807
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorSun XW(孙兴文)
Affiliation1.复旦大学
2.中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Sun QS,Zhu H,Chen YJ,et al. Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites[J]. Angew. Chem.-Int. Edit.,2015,54(45):13253-13257.
APA 孙强盛,朱华,陈永剑,杨笑迪,孙兴文,&林国强.(2015).Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites.Angew. Chem.-Int. Edit.,54(45),13253-13257.
MLA 孙强盛,et al."Squaramide-Catalyzed Synthesis of Enantioenriched Spirocyclic Oxindoles via Ketimine Intermediates with Multiple Active Sites".Angew. Chem.-Int. Edit. 54.45(2015):13253-13257.
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