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A Formal Synthesis of Betamethasone
Alternative Title倍他米松的形式合成
Wang SS(王莎莎); Shi Y(史勇); Tian WS(田伟生)
Source PublicationChin. J. Chem.
AbstractA formal synthesis of betamethasone from 5 alpha-pregnane-3 beta, 16 beta, 20S-triol is described. Key transformations are a bromination-acetylation of triol, an S(N)2 reaction of the resulting C16 alpha-bromide with dimethylcopperlithium to get the required C16 beta-methyl group, and a double hydroxylation to prepare the dihydroxyacetone side chain.
Subject Area天然产物有机化学
Indexed BySCI
WOS IDWOS:000356425200005
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Document Type期刊论文
Corresponding AuthorShi Y(史勇); Tian WS(田伟生)
Affiliation中科院上海有机化学研究所, 天然产物有机合成化学重点实验室
Recommended Citation
GB/T 7714
Wang SS,Shi Y,Tian WS. A Formal Synthesis of Betamethasone[J]. Chin. J. Chem.,2015,33(6):637-642.
APA 王莎莎,史勇,&田伟生.(2015).A Formal Synthesis of Betamethasone.Chin. J. Chem.,33(6),637-642.
MLA 王莎莎,et al."A Formal Synthesis of Betamethasone".Chin. J. Chem. 33.6(2015):637-642.
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