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学科主题: 天然产物有机化学
题名: A Formal Synthesis of Betamethasone
其他题名: 倍他米松的形式合成
作者: Wang SS(王莎莎); Shi Y(史勇); Tian WS(田伟生)
通讯作者: 史勇 ; 田伟生
刊名: Chin. J. Chem.
发表日期: 2015
DOI: 10.1002/cjoc.201500335
卷: 33, 期:6, 页:637-642
收录类别: SCI
文章类型: 论文
英文摘要: A formal synthesis of betamethasone from 5 alpha-pregnane-3 beta, 16 beta, 20S-triol is described. Key transformations are a bromination-acetylation of triol, an S(N)2 reaction of the resulting C16 alpha-bromide with dimethylcopperlithium to get the required C16 beta-methyl group, and a double hydroxylation to prepare the dihydroxyacetone side chain.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000356425200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39796
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所, 天然产物有机合成化学重点实验室

Recommended Citation:
Wang SS,Shi Y,Tian WS. A Formal Synthesis of Betamethasone[J]. Chin. J. Chem.,2015,33(6):637-642.
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