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Facile synthesis of solasodine based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins
Alternative Title基于甾体皂甙元卤代开环反应合成solasodine
Wu JJ(吴晶晶); Shi Y(史勇); Tian WS(田伟生)
2015
Source PublicationTetrahedron Lett.
Volume56Issue:10Pages:1215-1217
AbstractHerein we report a halogenation-ring opening reaction of spiroketals in steroidal sapogenins at room temperature to gain highly valuable omega-halo enol ethers in excellent yields. Boosted by this method, we have prepared solasodine, an antitumor steroidal alkaloid, from diosgenin acetate in three steps with an overall yield of 50%. (C) 2015 Elsevier Ltd. All rights reserved.
Subtype论文
Subject Area天然产物有机化学
DOI10.1016/j.tetlet.2015.01.149
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000350528300011
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39780
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorShi Y(史勇); Tian WS(田伟生)
Affiliation中科院上海有机化学研究所, 天然产物有机合成化学重点实验室
Recommended Citation
GB/T 7714
Wu JJ,Shi Y,Tian WS. Facile synthesis of solasodine based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins[J]. Tetrahedron Lett.,2015,56(10):1215-1217.
APA 吴晶晶,史勇,&田伟生.(2015).Facile synthesis of solasodine based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins.Tetrahedron Lett.,56(10),1215-1217.
MLA 吴晶晶,et al."Facile synthesis of solasodine based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins".Tetrahedron Lett. 56.10(2015):1215-1217.
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