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Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes
Alternative Title高效构建双环[4.3.0]壬烷: 铜催化的含有联烯结构的环己二烯酮的不对称硅化环化反应
He ZT(何智涛); Tang XQ(唐小齐); Xie LB(谢立波); Cheng M(成沔); Tian P(田平); Lin GQ(林国强)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:49Pages:14815-14818
AbstractThe creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Through regioselective beta-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98%) and enantioselectivities (94-98% ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures.
Subtype论文
Subject Area氟化学
DOI10.1002/anie.201508125
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000367723400037
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39770
Collection中科院有机氟化学重点实验室
Corresponding AuthorLin GQ(林国强)
Affiliation中科院上海有机化学研究所, 天然产物有机合成化学重点实验室
Recommended Citation
GB/T 7714
He ZT,Tang XQ,Xie LB,et al. Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes[J]. Angew. Chem.-Int. Edit.,2015,54(49):14815-14818.
APA 何智涛,唐小齐,谢立波,成沔,田平,&林国强.(2015).Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes.Angew. Chem.-Int. Edit.,54(49),14815-14818.
MLA 何智涛,et al."Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes".Angew. Chem.-Int. Edit. 54.49(2015):14815-14818.
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