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学科主题: 氟化学
题名: Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes
其他题名: 高效构建双环[4.3.0]壬烷: 铜催化的含有联烯结构的环己二烯酮的不对称硅化环化反应
作者: He ZT(何智涛); Tang XQ(唐小齐); Xie LB(谢立波); Cheng M(成沔); Tian P(田平); Lin GQ(林国强)
通讯作者: 林国强
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201508125
卷: 54, 期:49, 页:14815-14818
收录类别: SCI
文章类型: 论文
英文摘要: The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Through regioselective beta-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98%) and enantioselectivities (94-98% ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000367723400037
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39770
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所, 天然产物有机合成化学重点实验室

Recommended Citation:
He ZT,Tang XQ,Xie LB,et al. Efficient Access to Bicyclo[4.3.0]nonanes: Copper-Catalyzed Asymmetric Silylative Cyclization of Cyclohexadienone-Tethered Allenes[J]. Angew. Chem.-Int. Edit.,2015,54(49):14815-14818.
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