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学科主题: 氟化学
题名: Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction
其他题名: 用RuAAC反应合成含氟的1,4,5-取代-1,2,3-三唑
作者: Shen Q(沈倩)1; Han EJ(韩恩健)1; Huang YG(黄焰根)1; Chen QY(陈庆云)1; Guo Y(郭勇)1
通讯作者: 黄焰根 ; 陈庆云 ; 郭勇
刊名: Synthesis
发表日期: 2015
DOI: 10.1055/s-0035-1560352
卷: 47, 期:24, 页:3936-3946
收录类别: SCI
文章类型: 论文
英文摘要: Herein, we report a convenient methodology for the synthesis of fluorinated 1,4,5-substituted 1,2,3-triazoles. The azide-alkyne cycloaddition reaction of internal alkynes catalyzed by a ruthenium complex efficiently afforded 2,2,2-trifluoroethyl- and (trifluoromethyl)thio-substituted 1,2,3-triazoles. Two types of internal alkyne, 1-aryl-2-(2,2,2-trifluoroethyl)acetylenes and 1-aryl-2-[(trifluoromethyl)thio]acetylenes, were used. This ruthenium-catalyzed azide-alkyne cycloaddition reaction was highly regioselective giving 4-aryl-5-(2,2,2-trifluoroethyl)- or 4-aryl-5-[(trifluoromethyl)thio]-1H-1,2,3-triazoles. Various functionalities were tolerated in the alkyl and aryl azides by this Huisgen 1,3-dipolar cycloaddition. All the triazoles were characterized by H-1, C-13, and F-19 NMR, IR, and HRMS (or elemental analysis). Several triazoles were characterized by single-crystal X-ray structural analysis to confirm the regioselectivity of 1,2,3-triazole formation.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000366209800013
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39766
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 1.东华大学
2.中科院上海有机化学研究所, 有机氟化学重点实验室

Recommended Citation:
Shen Q,Han EJ,Huang YG,et al. Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction[J]. Synthesis,2015,47(24):3936-3946.
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