SIOC OpenIR  > 中科院有机氟化学重点实验室
Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction
其他题名用RuAAC反应合成含氟的1,4,5-取代-1,2,3-三唑
Shen Q(沈倩)1; Han EJ(韩恩健)1; Huang YG(黄焰根)1; Chen QY(陈庆云)1; Guo Y(郭勇)1
2015
发表期刊Synthesis
卷号47期号:24页码:3936-3946
摘要Herein, we report a convenient methodology for the synthesis of fluorinated 1,4,5-substituted 1,2,3-triazoles. The azide-alkyne cycloaddition reaction of internal alkynes catalyzed by a ruthenium complex efficiently afforded 2,2,2-trifluoroethyl- and (trifluoromethyl)thio-substituted 1,2,3-triazoles. Two types of internal alkyne, 1-aryl-2-(2,2,2-trifluoroethyl)acetylenes and 1-aryl-2-[(trifluoromethyl)thio]acetylenes, were used. This ruthenium-catalyzed azide-alkyne cycloaddition reaction was highly regioselective giving 4-aryl-5-(2,2,2-trifluoroethyl)- or 4-aryl-5-[(trifluoromethyl)thio]-1H-1,2,3-triazoles. Various functionalities were tolerated in the alkyl and aryl azides by this Huisgen 1,3-dipolar cycloaddition. All the triazoles were characterized by H-1, C-13, and F-19 NMR, IR, and HRMS (or elemental analysis). Several triazoles were characterized by single-crystal X-ray structural analysis to confirm the regioselectivity of 1,2,3-triazole formation.
文章类型论文
学科领域氟化学
DOI10.1055/s-0035-1560352
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000366209800013
引用统计
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39766
专题中科院有机氟化学重点实验室
通讯作者Huang YG(黄焰根); Chen QY(陈庆云); Guo Y(郭勇)
作者单位1.东华大学
2.中科院上海有机化学研究所, 有机氟化学重点实验室
推荐引用方式
GB/T 7714
Shen Q,Han EJ,Huang YG,et al. Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction[J]. Synthesis,2015,47(24):3936-3946.
APA 沈倩,韩恩健,黄焰根,陈庆云,&郭勇.(2015).Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction.Synthesis,47(24),3936-3946.
MLA 沈倩,et al."Synthesis of Fluorinated 1,4,5-Substituted 1,2,3-Triazoles by RuAAC Reaction".Synthesis 47.24(2015):3936-3946.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2015660.pdf(1120KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[沈倩]的文章
[韩恩健]的文章
[黄焰根]的文章
百度学术
百度学术中相似的文章
[沈倩]的文章
[韩恩健]的文章
[黄焰根]的文章
必应学术
必应学术中相似的文章
[沈倩]的文章
[韩恩健]的文章
[黄焰根]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。