SIOC OpenIR  > 中科院有机氟化学重点实验室
Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides
Alternative Title镍催化下(杂)芳基碘代物与氟代二级溴代烷烃的还原偶联反应
Li XF(李学飞)1; Feng Z(冯璋)1; Jiang ZX(江中兴)1; Zhang XG(张新刚)1
2015
Source PublicationOrg. Lett.
Volume17Issue:22Pages:5570-5573
AbstractA mild and efficient nickel-catalyzed reductive cross-coupling between fluorinated secondary alkyl bromides and (hetero)aryl iodides is described. The use of FeBr2 as an additive successfully overcomes the hydrodebromination and beta-fluorine elimination of fluorinated substrates and allows the efficient synthesis of a wide range of trifluoromethyl and difluoroalkyl containing aliphatic compounds with a fluoroalkyl substituted tertiary carbon center. The notable features of this protocol are the synthetic and operational simplicity without preparation of moisture sensitive organometallic reagents and excellent functional group compatibility, even toward active proton containing substrates.
Subtype论文
Subject Area氟化学
DOI10.1021/acs.orglett.5b02716
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000365462900015
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39763
Collection中科院有机氟化学重点实验室
Corresponding AuthorJiang ZX(江中兴); Zhang XG(张新刚)
Affiliation1.武汉大学
2.中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Li XF,Feng Z,Jiang ZX,et al. Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides[J]. Org. Lett.,2015,17(22):5570-5573.
APA 李学飞,冯璋,江中兴,&张新刚.(2015).Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides.Org. Lett.,17(22),5570-5573.
MLA 李学飞,et al."Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides".Org. Lett. 17.22(2015):5570-5573.
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