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Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)
Alternative Title用1,1-二氯-2,2,2-三氟乙烷(HCFC-123)的铜促-2,2,2-三氟乙基化反应
Han EJ(韩恩健)1; Sun Y(孙岩)1; Shen Q(沈倩)1; Chen QY(陈庆云)1; Guo Y(郭勇)1; Huang YG(黄焰根)1
2015
Source PublicationOrg. Chem. Front.
Volume2Issue:10Pages:1379-1387
AbstractThe title reaction provides a novel utilization of ozone-depleting/global-warming HCFCs as a new carbon-carbon cross-coupling model of various terminal alkynes by activating two inert C-Cl bonds successively. This protocol provided trifluoroethylated alkynes efficiently under mild reaction conditions and was compatible with a broad range of functional groups. An example of the synthesis of a terbinafine analogue is shown. Some mechanistic experiments including deuterated reagents and radical/SET inhibitors are described.
Subtype论文
Subject Area氟化学
DOI10.1039/c5qo00210a
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000364450000015
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39759
Collection中科院有机氟化学重点实验室
Corresponding AuthorChen QY(陈庆云); Guo Y(郭勇)
Affiliation1.中科院上海有机化学研究所, 有机氟化学重点实验室
2.东华大学
Recommended Citation
GB/T 7714
Han EJ,Sun Y,Shen Q,et al. Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)[J]. Org. Chem. Front.,2015,2(10):1379-1387.
APA 韩恩健,孙岩,沈倩,陈庆云,郭勇,&黄焰根.(2015).Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123).Org. Chem. Front.,2(10),1379-1387.
MLA 韩恩健,et al."Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)".Org. Chem. Front. 2.10(2015):1379-1387.
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