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Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids
Alternative Title通过钯催化芳基硼酸的二氟烷基化合成二芳基二氟甲烷
Gu JW(顾继伟); Guo WH(郭文豪); Zhang XG(张新刚)
2015
Source PublicationOrg. Chem. Front.
Volume2Issue:1Pages:38-41
AbstractDiaryldifluoromethanes constitute a distinct class of fluorinated compounds in medicinal chemistry. But only limited methods to access this structural motif have been reported. Herein, we demonstrate the first example of Pd-catalyzed aryldifluoromethylation of arylboronic acids with readily available aryldifluoromethyl bromides. Because of its high efficiency, excellent functional group compatibility, and mild reaction conditions, this protocol provides a facile access to diaryldifluoromethanes. Preliminary mechanistic studies revealed that a Pd(0) L-n-initiated single electron transfer (SET) pathway is involved in the catalytic cycle.
Subtype论文
Subject Area氟化学
DOI10.1039/c4qo00246f
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000364442500007
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39755
Collection中科院有机氟化学重点实验室
Corresponding AuthorZhang XG(张新刚)
Affiliation中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Gu JW,Guo WH,Zhang XG. Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids[J]. Org. Chem. Front.,2015,2(1):38-41.
APA 顾继伟,郭文豪,&张新刚.(2015).Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids.Org. Chem. Front.,2(1),38-41.
MLA 顾继伟,et al."Synthesis of diaryldifluoromethanes by Pd-catalyzed difluoroalkylation of arylboronic acids".Org. Chem. Front. 2.1(2015):38-41.
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