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Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles
Alternative Title源于二氟卡宾的脂肪族亲电物种的三氟甲硫基化及氟-18标记
Zheng J(郑剑)1; Wang L(王璐)1; Lin JH(林锦鸿)1; Xiao JC(肖吉昌)1; Liang H(梁欢)1
Source PublicationAngew. Chem.-Int. Edit.
AbstractThe first trifluoromethylthiolation and [F-18]trifluoromethylthiolation of alkyl electrophiles with insitu generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition-metal-free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous-fluoride-mediated transformation enables unprecedented syntheses of [F-18]CF3S-labeled molecules from most commonly used [F-18]fluoride ions. The rapid radiochemical reaction time (1min) and high functional-group tolerance allow access to a variety of aliphatic [F-18]CF3S compounds in high yields.
Subject Area氟化学
Indexed BySCI
WOS IDWOS:000363691500011
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Document Type期刊论文
Corresponding AuthorXiao JC(肖吉昌); Liang H(梁欢)
Affiliation1.中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Zheng J,Wang L,Lin JH,et al. Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles[J]. Angew. Chem.-Int. Edit.,2015,54(45):13236-13240.
APA 郑剑,王璐,林锦鸿,肖吉昌,&梁欢.(2015).Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles.Angew. Chem.-Int. Edit.,54(45),13236-13240.
MLA 郑剑,et al."Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles".Angew. Chem.-Int. Edit. 54.45(2015):13236-13240.
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