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学科主题: 氟化学
题名: Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles
其他题名: 源于二氟卡宾的脂肪族亲电物种的三氟甲硫基化及氟-18标记
作者: Zheng J(郑剑)1; Wang L(王璐)1; Lin JH(林锦鸿)1; Xiao JC(肖吉昌)1; Liang H(梁欢)1
通讯作者: 肖吉昌 ; 梁欢
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201505446
卷: 54, 期:45, 页:13236-13240
收录类别: SCI
文章类型: 论文
英文摘要: The first trifluoromethylthiolation and [F-18]trifluoromethylthiolation of alkyl electrophiles with insitu generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition-metal-free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous-fluoride-mediated transformation enables unprecedented syntheses of [F-18]CF3S-labeled molecules from most commonly used [F-18]fluoride ions. The rapid radiochemical reaction time (1min) and high functional-group tolerance allow access to a variety of aliphatic [F-18]CF3S compounds in high yields.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000363691500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39752
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 有机氟化学重点实验室
2.美国哈佛大学

Recommended Citation:
Zheng J,Wang L,Lin JH,et al. Difluorocarbene-Derived Trifluoromethylthiolation and [F-18]Trifluoromethylthiolation of Aliphatic Electrophiles[J]. Angew. Chem.-Int. Edit.,2015,54(45):13236-13240.
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