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Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers
Alternative Title银参与酚的氧化三氟甲基化反应: 芳基三氟甲基醚的直接合成
Liu JB(刘建波)1; Chen C(陈超)1; Chu LL(储玲玲)1; Chen ZH(陈增浩)1; Xu XH(徐修华)1; Qing FL(卿凤翎)1
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:40Pages:11839-11842
AbstractAryl trifluoromethyl ethers (ArOCF3) are prevalent in pharmaceuticals, agrochemicals, and materials. However, methods for the general and efficient synthesis of these compounds are extremely underdeveloped and limited. Herein, we describe a highly efficient and general procedure for the direct O-trifluoromethylation of unprotected phenols through a silver-mediated cross-coupling reaction using CF3SiMe3 as the CF3 source and exogenous oxidants. This novel oxidative trifluoromethylation provides access to a wide range of aryl trifluoromethyl ethers from simple phenols. The mild process was also applied to the late-stage trifluoromethylation of a medicinally relevant compound.
Subtype论文
Subject Area氟化学
DOI10.1002/anie.201506329
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000363394800045
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39750
Collection中科院有机氟化学重点实验室
Corresponding AuthorQing FL(卿凤翎)
Affiliation1.中科院上海有机化学研究所, 有机氟化学重点实验室
2.东华大学
Recommended Citation
GB/T 7714
Liu JB,Chen C,Chu LL,et al. Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers[J]. Angew. Chem.-Int. Edit.,2015,54(40):11839-11842.
APA 刘建波,陈超,储玲玲,陈增浩,徐修华,&卿凤翎.(2015).Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers.Angew. Chem.-Int. Edit.,54(40),11839-11842.
MLA 刘建波,et al."Silver-Mediated Oxidative Trifluoromethylation of Phenols: Direct Synthesis of Aryl Trifluoromethyl Ethers".Angew. Chem.-Int. Edit. 54.40(2015):11839-11842.
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