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Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides
Alternative Title钯催化下烯烃与二氟烷基的Heck反应
Feng Z(冯璋); Min QQ(闵巧桥); Zhang XG(张新刚)
2015
Source PublicationSynthesis
Volume47Issue:19Pages:2912-2923
AbstractAn efficient method for the synthesis of difluoroalkylated alkenes through palladium-catalyzed Heck-type reaction with functionalized difluoromethyl bromides has been developed. The advantages of this protocol are its synthetic simplicity, excellent functional group compatibility, and efficient late-stage difluoroalkylation of biologically relevant molecules, thus paving a new way for application in drug discovery and development. Mechanistic studies revealed that the free difluoroalkyl radicals, initiated by a [Pd(0)L-n] via a single-electron-transfer (SET) pathway, were involved in the Heck-type catalytic cycle.
Subtype论文
Subject Area氟化学
DOI10.1055/s-0035-1560457
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000362568400007
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39747
Collection中科院有机氟化学重点实验室
Corresponding AuthorZhang XG(张新刚)
Affiliation中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Feng Z,Min QQ,Zhang XG. Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides[J]. Synthesis,2015,47(19):2912-2923.
APA 冯璋,闵巧桥,&张新刚.(2015).Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides.Synthesis,47(19),2912-2923.
MLA 冯璋,et al."Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides".Synthesis 47.19(2015):2912-2923.
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