中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 中科院有机氟化学重点实验室  > 期刊论文
学科主题: 氟化学
题名: Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides
其他题名: 钯催化下烯烃与二氟烷基的Heck反应
作者: Feng Z(冯璋); Min QQ(闵巧桥); Zhang XG(张新刚)
通讯作者: 张新刚
刊名: Synthesis
发表日期: 2015
DOI: 10.1055/s-0035-1560457
卷: 47, 期:19, 页:2912-2923
收录类别: SCI
文章类型: 论文
英文摘要: An efficient method for the synthesis of difluoroalkylated alkenes through palladium-catalyzed Heck-type reaction with functionalized difluoromethyl bromides has been developed. The advantages of this protocol are its synthetic simplicity, excellent functional group compatibility, and efficient late-stage difluoroalkylation of biologically relevant molecules, thus paving a new way for application in drug discovery and development. Mechanistic studies revealed that the free difluoroalkyl radicals, initiated by a [Pd(0)L-n] via a single-electron-transfer (SET) pathway, were involved in the Heck-type catalytic cycle.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000362568400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39747
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2015501.pdf(1276KB)期刊论文作者接受稿开放获取View Download

作者单位: 中科院上海有机化学研究所, 有机氟化学重点实验室

Recommended Citation:
Feng Z,Min QQ,Zhang XG. Palladium-Catalyzed Heck-Type Difluoroalkylation of Alkenes with Functionalized Difluoromethyl Bromides[J]. Synthesis,2015,47(19):2912-2923.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[冯璋]'s Articles
[闵巧桥]'s Articles
[张新刚]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[冯璋]‘s Articles
[闵巧桥]‘s Articles
[张新刚]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2015501.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace