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N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation
Alternative TitleN-二氟甲硫基邻苯酰亚胺: 一个稳定的亲电二氟甲硫基试剂
Zhu DH(朱佃虎); Gu Y(古阳); Lv L(吕龙); Shen QL(沈其龙)
Source PublicationJ. Am. Chem. Soc.
AbstractA new, electrophilic difluoromethylthiolating reagent N-difluoromethylthiophthalimide 3 was developed. Reagent 3 can be readily synthesized in four steps from easily available starting materials phthalimide and TMSCF2H. N-difluoromethylthiophthalimide 3 is a powerful electrophilic difluoromethylthiolating reagent that allows the difluoromethylthiolation of a wide range of nucleophiles including aryl/vinyl boronic acids, alkynes, amines, thiols, beta-ketoesters, and oxindoles and electron-rich heteroarenes such as indole, pyrrole, 1H-pyrrolo[2,3-b]pyridine, imidazo[1,2-a]pyridine, aminothiazole, isoxazole, and pyrazole under mild conditions.
Subject Area氟化学
Indexed BySCI
WOS IDWOS:000360321100025
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Document Type期刊论文
Corresponding AuthorLv L(吕龙); Shen QL(沈其龙)
Affiliation中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Zhu DH,Gu Y,Lv L,et al. N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation[J]. J. Am. Chem. Soc.,2015,137(33):10547-10553.
APA 朱佃虎,古阳,吕龙,&沈其龙.(2015).N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation.J. Am. Chem. Soc.,137(33),10547-10553.
MLA 朱佃虎,et al."N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation".J. Am. Chem. Soc. 137.33(2015):10547-10553.
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