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学科主题: 有机化学
题名: 2-(吡啶-2-甲酰基)嘧啶类化合物的合成与生物活性研究
其他题名: Synthesis and Bioactivity of 2-(Pyridyl-2-formyl)pyrimidine Derivatives
作者: 吕强1; 芦昕婷1; 张基胜1; 张志国1; 朱为宏1; 杜葩1; 吕龙1
通讯作者: 杜葩
刊名: 有机化学
发表日期: 2015
DOI: 10.6023/cjoc201412034
卷: 35, 期:6, 页:1342-1347
收录类别: SCI
文章类型: 论文
英文摘要: Based on the structural optimization of 2-benzoyl pyrimidine derivatives, eight 2-(pyridyl-2-formyl)pyrimidine derivatives have been specifically designed and synthesized for evaluation of their interior fungicidal activities. 2-(Pyridyl-2-formyl)pyrimidine derivatives show excellent activity against cucumber downy mildew and cucumber powdery mildew. Among them, 2-chloro-N-{[2-(4,6-dimethoxypyrimidine-2-carbonyl)pyridin-3-yl]oxy}-N-methylbenzamide (6b) exhibits comparable protective and curative activity against cucumber powdery mildew to reference Metrafenone. EC50 and EC90 of the protective activity are 0.69 and 2.89 mg/L, respectively, and those of curative activity are 0.13 and 1.6 mg/L. 6b also shows excellent upward translocation in plants and rainfast performance. Especially, its persistent efficacy period of the protective activity against cucumber powdery mildew can last 15 similar to 20 d.
语种: 中文
相关网址: 查看原文
WOS记录号: WOS:000359274400017
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39741
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 1.华东理工大学
2.中科院上海有机化学研究所, 有机氟化学重点实验室
3.上海应用技术学院

Recommended Citation:
吕强,芦昕婷,张基胜,等. 2-(吡啶-2-甲酰基)嘧啶类化合物的合成与生物活性研究[J]. 有机化学,2015,35(6):1342-1347.
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