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学科主题: 有机化学
题名: 2-苯甲酰基嘧啶类化合物的合成与生物活性
其他题名: Synthesis and Bioactivity of 2-Benzoyl Pyrimidine Derivatives
作者: 吕强1; 芦昕婷1; 戴明1; 刘世梦1; 朱为宏1; 杜葩1; 吕龙1
通讯作者: 杜葩
刊名: 有机化学
发表日期: 2015
DOI: 10.6023/cjoc201412032
卷: 35, 期:6, 页:1260-1269
收录类别: SCI
文章类型: 论文
英文摘要: 2-Benzoyl pyrimidine as a secondary leading structure is developed by twice optimization of 2-pyrimidinoxy-N-aryl benzylamine. Based on this structure, thirty six 2-benzoyl pyrimidine derivatives have been designed and synthesized. All compounds are determined by H-1 NMR, C-13 NMR. and HRMS. Their interior fungicidal activities show that R-1 substituent prefers phenyl or heterocyclic group with 2-halo or 2-alkyl group. When introducing fluoride to 6-position on benzene ring, the fungicidal activity is maintained at a similar level. 4,6-Dimethoxy group on pyrimidine ring was recognized as a best substituent by far. The activity is seriously decreased when methyl group is fixed on 5-position of pyrimidine. Even the fungicidal activities become completely disappeared when the ketone group is reduced to hydroxyl group. Among them, three compounds 2,3-dichloro-N-(2-(4,6-dimethoxypyrimidine-2-carbonyl)phenoxy)-N-methylbenzamide (4AHI), 2,5-dichloro-N-(2-(4,6-dimethoxypyrimidine-2-carbonyl)phenoxy)-N-methylbenzamide (4AHn) and N-(2-(4,6-dimethoxypyrimidine-2-carbonyl)-3-fluorophenoxy)-N,2-dimethylbenzamide (4AFd) exhibit comparable fungicidal activity against cucumber powdery mildew to the reference metrafenone.
语种: 中文
相关网址: 查看原文
WOS记录号: WOS:000359274400007
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39740
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 1.华东理工大学
2.中科院上海有机化学研究所, 有机氟化学重点实验室
3.上海应用技术学院

Recommended Citation:
吕强,芦昕婷,戴明,等. 2-苯甲酰基嘧啶类化合物的合成与生物活性[J]. 有机化学,2015,35(6):1260-1269.
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