| Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide | |
| Alternative Title | 镍催化下芳基硼酸与氟溴甲烷的偶联反应 |
| An L(安伦); Xiao YL(肖玉兰); Min QQ(闵巧桥); Zhang XG(张新刚) | |
| 2015 | |
| Source Publication | Angew. Chem.-Int. Edit.
 |
| Volume | 54Issue:31Pages:9079-9083 |
| Abstract | The nickel-catalyzed fluoromethylation of arylboronic acids was achieved with the industrial raw material fluoromethyl bromide (CH2FBr) as the coupling partner. The reaction proceeded under mild reaction conditions with high efficiency; it features the use of a low-cost nickel catalyst, synthetic simplicity, and excellent functional-group compatibility, and provides facile access to fluoromethylated biologically relevant molecules. Preliminary mechanistic studies showed that a single-electron-transfer (SET) pathway is involved in the catalytic cycle. |
| Subtype | 论文 |
| Subject Area | 氟化学 |
| DOI | 10.1002/anie.201502882 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000358501500038 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sioc.ac.cn/handle/331003/39734 |
| Collection | 中科院有机氟化学重点实验室 |
| Corresponding Author | Zhang XG(张新刚) |
| Affiliation | 中科院上海有机化学研究所, 有机氟化学重点实验室 |
| Recommended Citation GB/T 7714 | An L,Xiao YL,Min QQ,et al. Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide[J]. Angew. Chem.-Int. Edit.,2015,54(31):9079-9083. |
| APA | 安伦,肖玉兰,闵巧桥,&张新刚.(2015).Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide.Angew. Chem.-Int. Edit.,54(31),9079-9083. |
| MLA | 安伦,et al."Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide".Angew. Chem.-Int. Edit. 54.31(2015):9079-9083. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2015371.pdf（696KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment