Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide

doi:10.1002/anie.201502882

	Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide
其他题名	镍催化下芳基硼酸与氟溴甲烷的偶联反应
	An L(安伦); Xiao YL(肖玉兰); Min QQ(闵巧桥); Zhang XG(张新刚)
	2015
发表期刊	Angew. Chem.-Int. Edit.
卷号	54 期号:31 页码:9079-9083
摘要	The nickel-catalyzed fluoromethylation of arylboronic acids was achieved with the industrial raw material fluoromethyl bromide (CH2FBr) as the coupling partner. The reaction proceeded under mild reaction conditions with high efficiency; it features the use of a low-cost nickel catalyst, synthetic simplicity, and excellent functional-group compatibility, and provides facile access to fluoromethylated biologically relevant molecules. Preliminary mechanistic studies showed that a single-electron-transfer (SET) pathway is involved in the catalytic cycle.
文章类型	论文
学科领域	氟化学
DOI	10.1002/anie.201502882
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000358501500038
引用统计
文献类型	期刊论文
条目标识符	http://ir.sioc.ac.cn/handle/331003/39734
专题	中科院有机氟化学重点实验室
通讯作者	Zhang XG(张新刚)
作者单位	中科院上海有机化学研究所, 有机氟化学重点实验室
推荐引用方式 GB/T 7714	An L,Xiao YL,Min QQ,et al. Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide[J]. Angew. Chem.-Int. Edit.,2015,54(31):9079-9083.
APA	安伦,肖玉兰,闵巧桥,&张新刚.(2015).Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide.Angew. Chem.-Int. Edit.,54(31),9079-9083.
MLA	安伦,et al."Facile Access to Fluoromethylated Arenes by Nickel-Catalyzed Cross-Coupling between Arylboronic Acids and Fluoromethyl Bromide".Angew. Chem.-Int. Edit. 54.31(2015):9079-9083.

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