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Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts
Alternative TitleCopper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts
Wu J(吴江); Gu Y(古阳); Leng XB(冷雪冰); Shen QL(沈其龙)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:26Pages:7648-7652
AbstractAn efficient copper-promoted difluoromethylthiolation of aryl and heteroaryl diazonium salts is described. The reaction is conducted under mild reaction conditions and various functional groups were compatible. In addition, reactions of heteroaryl diazonium salts such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl, and pyrazolyl diazonium salts occurred smoothly to afford the medicinally important difluoromethylthiolated heteroarenes. Furthermore, a more practical one-pot direct diazotization and difluoromethylthiolation protocol was developed, and it converts the aniline derivatives into difluoromethylthiolated arenes. The utility of the method is demonstrated by difluoromethylthiolation of a number of natural products and drug molecules.
Subtype论文
Subject Area氟化学
DOI10.1002/anie.201502113
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000356390900035
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39727
Collection中科院有机氟化学重点实验室
Corresponding AuthorShen QL(沈其龙)
Affiliation中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Wu J,Gu Y,Leng XB,et al. Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts[J]. Angew. Chem.-Int. Edit.,2015,54(26):7648-7652.
APA 吴江,古阳,冷雪冰,&沈其龙.(2015).Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts.Angew. Chem.-Int. Edit.,54(26),7648-7652.
MLA 吴江,et al."Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts".Angew. Chem.-Int. Edit. 54.26(2015):7648-7652.
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