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Metal-Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine
Alternative Title金属促进的溴二氟甲基酮和亚胺的Reformatsky反应
Cao CR(曹春如); Jiang M(蒋敏); Liu JT(刘金涛)
Source PublicationEur. J. Org. Chem.
AbstractThe Reformatsky reaction of bromodifluoromethyl ketones and imines took place readily in the presence of Zn/CuCl at room temperature to afford beta-amino alpha,alpha-difluoro ketones in good yields. Using (S)-tert-butanesulfinyl as a chiral auxiliary, the asymmetric Reformatsky reaction was also achieved and found to proceed with excellent diastereoselectivities. A plausible model is proposed to account for the high stereoselectivity of the reaction.
Subject Area氟化学
Indexed BySCI
WOS IDWOS:000349391700028
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu JT(刘金涛)
Affiliation中科院上海有机化学研究所, 有机氟化学重点实验室
Recommended Citation
GB/T 7714
Cao CR,Jiang M,Liu JT. Metal-Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine[J]. Eur. J. Org. Chem.,2015(5):1144-1151.
APA 曹春如,蒋敏,&刘金涛.(2015).Metal-Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine.Eur. J. Org. Chem.(5),1144-1151.
MLA 曹春如,et al."Metal-Mediated Reformatsky Reaction of Bromodifluoromethyl Ketone and Imine".Eur. J. Org. Chem. .5(2015):1144-1151.
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