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Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry
Alternative Title电喷雾离子迁移质谱表征脂肪酸的离子迁移和碰撞截面
Zhang F(张芳)1; Guo S(郭甦)1; Zhang MY(张曼玉)1; Zhang ZX(张之旭)1; Guo YL(郭寅龙)1
2015
Source PublicationJ. Mass Spectrom.
Volume50Issue:7Pages:906-913
AbstractThis study investigated the ion mobility (IM) and the collision cross section (CCS) of fatty acids (FAs) using electrospray IM MS. The IM analysis of 18 FA ions showed intriguing differences among the saturated FAs, monounsaturated FAs, multi-unsaturated FAs, and cis-isomer/trans-isomer with respect to the aliphatic tail chains. The length of aliphatic tail chain present in the ion structures had a strong influence on the differentiation of drift, while the number of double bond showed a weaker influence. The tiny drift differences between cis-isomer and trans-isomer were also observed. In the CCS measurements, two internal standards were involved in the mobility calibration and accuracy estimation. It insured our empirical CCS values were of high experimental precision (+/- 0.35% or better) and accuracy (+/- 0.25% or better). Moreover, the mass-to-charge ratio (m/z) - mobility plots obtained by ion mobility spectrometry with mass spectrometry analysis of FAs - was used to investigate the structural relationship between the molecules. Each series of FAs sharing a similar structure was aligned in the linear plot. Finally, the developed procedure was applied to the determination of FAs in rat adipose tissues, and it allowed the presence of 13 FAs to be confirmed with their exact masses and CCS values. These studies reveal the direct relationship between the behaviors in IM and the molecular structures and thus may provide further validations to the FA identification process. Copyright (C) 2015 John Wiley & Sons, Ltd.
Subtype论文
Subject Area分析化学
DOI10.1002/jms.3600
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000359273200005
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39692
Collection分析化学研究室
Corresponding AuthorGuo YL(郭寅龙)
Affiliation1.中科院上海有机化学研究所, 上海质谱中心
2.复旦大学
3.安捷伦科技(中国)有限公司
Recommended Citation
GB/T 7714
Zhang F,Guo S,Zhang MY,et al. Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry[J]. J. Mass Spectrom.,2015,50(7):906-913.
APA 张芳,郭甦,张曼玉,张之旭,&郭寅龙.(2015).Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry.J. Mass Spectrom.,50(7),906-913.
MLA 张芳,et al."Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry".J. Mass Spectrom. 50.7(2015):906-913.
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