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Asymmetric H2O-Nucleophilic Ring Opening of D-A Cyclopropanes: Catalyst Serves as a Source of Water
Alternative Title水亲核的推拉电子环丙烷不对称开环反应: 催化剂作为水源
Kang QK(康麒凯)1; Wang LJ(王丽佳)1; Liu QJ(刘琼杰)1; Li JF(李军方)1; Tang Y(唐勇)1
2015
Source PublicationJ. Am. Chem. Soc.
Volume137Issue:46Pages:14594-14597
AbstractThe first catalytic enantioselective ring-opening reaction of donoracceptor cyclopropanes with water is described. By employing Cy-TOX/Cu(II) as catalyst, the reaction performed very well over a broad range of substrates, leading to the ring-opening products in 7096% yields with up to 95% ee under mild conditions. The current method provides a new approach to direct access to gamma-substituted GBH derivatives very efficiently. Importantly, Cu(ClO4)(2)center dot 6H(2)O proves to serve as both a Lewis acid and a source of water, which affords a fine system to controllably release water as a nucleophile in the asymmetric catalysis.
Subtype论文
Subject Area金属有机化学
DOI10.1021/jacs.5b10310
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000366004700011
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39675
Collection金属有机化学国家重点实验室
Corresponding AuthorTang Y(唐勇)
Affiliation1.中科院上海有机化学研究所, 金属有机化学国家重点实验室
2.天津化学化工协同创新中心
Recommended Citation
GB/T 7714
Kang QK,Wang LJ,Liu QJ,et al. Asymmetric H2O-Nucleophilic Ring Opening of D-A Cyclopropanes: Catalyst Serves as a Source of Water[J]. J. Am. Chem. Soc.,2015,137(46):14594-14597.
APA 康麒凯,王丽佳,刘琼杰,李军方,&唐勇.(2015).Asymmetric H2O-Nucleophilic Ring Opening of D-A Cyclopropanes: Catalyst Serves as a Source of Water.J. Am. Chem. Soc.,137(46),14594-14597.
MLA 康麒凯,et al."Asymmetric H2O-Nucleophilic Ring Opening of D-A Cyclopropanes: Catalyst Serves as a Source of Water".J. Am. Chem. Soc. 137.46(2015):14594-14597.
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