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学科主题: 金属有机化学
题名: Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives
其他题名: 钯催化高对映选择性合成平面手性二茂铁吡啶衍生物
作者: Gao DW(高得伟)1; Zheng C(郑超)1; Gu Q(顾庆)1; You SL(游书力)1
通讯作者: 顾庆 ; 游书力
刊名: Organometallics
发表日期: 2015
DOI: 10.1021/acs.organomet.5b00730
卷: 34, 期:18, 页:4618-4625
收录类别: SCI
文章类型: 论文
英文摘要: A highly efficient synthesis of planar chiral ferrocenylpyridine derivatives via Pd-catalyzed intramolecular C-H arylation was developed, and quantitative yields and excellent enantioselectivity were obtained for a wide range of substrates. Notably, the catalyst loading could be lowered to 0.2 mol %, which represents the highest catalytic efficiency found for asymmetric C-H bond activation (TON up to 495). These compounds could be easily transformed to pyridine N-oxides, displaying promising catalytic reactivity in the asymmetric opening of meso-epoxide. Moreover, computational investigations were conducted to clarify the origin of the excellent enantioselectivity. The compatibility of large-scale synthesis and low catalyst loading should enhance the practicality of the synthetic application of the current method.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000362056400021
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39643
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 金属有机化学国家重点实验室
2.天津化学化工协同创新中心

Recommended Citation:
Gao DW,Zheng C,Gu Q,et al. Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives[J]. Organometallics,2015,34(18):4618-4625.
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