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Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions
Alternative Title通过铱催化的不对称烯丙基去芳构化和可控的迁移反应不对称合成螺环和多环吡咯衍生物
Zhuo CX(卓春祥); Cheng Q(程强); Liu WB(刘文博); Zhao Q(赵强); You SL(游书力)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:29Pages:8475-8479
AbstractThe first highly diastereo- and enantioselective synthesis of five-membered spiro-2H-pyrroles was achieved using an Ir-catalyzed asymmetric allylic dearomatization reaction. The spiro-2H-pyrrole derivatives readily undergo a controllable and stereospecific allylic migration under acid catalysis, providing polycyclic pyrrole derivatives in excellent yields and ee values. Additionally, the novel Ir-complex K1, derived from [Ir(cod) Cl](2) (cod= 1,5-cyclooctadiene) and N-benzhydryl-N-phenyldinaphthophosphoramidite (BHPphos), showed excellent control of both diastereo- and enantioselectivities.
Subtype论文
Subject Area金属有机化学
DOI10.1002/anie.201502259
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000358050300029
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39620
Collection金属有机化学国家重点实验室
Corresponding AuthorYou SL(游书力)
Affiliation中科院上海有机化学研究所, 金属有机化学国家重点实验室
Recommended Citation
GB/T 7714
Zhuo CX,Cheng Q,Liu WB,et al. Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions[J]. Angew. Chem.-Int. Edit.,2015,54(29):8475-8479.
APA 卓春祥,程强,刘文博,赵强,&游书力.(2015).Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions.Angew. Chem.-Int. Edit.,54(29),8475-8479.
MLA 卓春祥,et al."Enantioselective Synthesis of Pyrrole-Based Spiro- and Polycyclic Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions".Angew. Chem.-Int. Edit. 54.29(2015):8475-8479.
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