A cadmium iodide mediated tandem reaction involving amine and two molecules of terminal alkynes for the synthesis of trisubstituted allenes has been developed. By applying this protocol, methyl-substituted allenes may be obtained easily from two molecules of terminal alkynes and pyrrolidine via methyl ketoniminium and propargylic amine formation, 1,5-hydride transfer and beta-elimination.
Tang XJ,Han YL,Ma SM. Cadmium Iodide Mediated Allenylation of Terminal Alkynes for the Synthesis of Methyl-Substituted Allenes[J]. Org. Lett.,2015,17(5):1176-1179.
