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A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols
Alternative Title一种普遍且温和的利用醇进行非活化酯的alfa烷基化方法
Guo L(郭乐); Ma XC(马笑晨); Fang HQ(方华权); Jia XQ(贾香清); Huang Z(黄正)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:13Pages:4023-4027
AbstractCatalytic alpha-alkylation of esters with primary alcohols is a desirable process because it uses low-toxicity agents and generates water as the by-product. Reported herein is a NCP pincer/Ir catalyst which is highly efficient for alpha-alkylation of a broad scope of unactivated esters under mild reaction conditions. For the first time, alcohols alkylate unactivated a-substituted acyclic esters, lactones, and even methyl and ethyl acetates. This method can be applied to the synthesis of carboxylic acid derivatives with diverse structures and functional groups, some of which would be impossible to access by conventional enolate alkylations with alkyl halides.
Subtype论文
Subject Area金属有机化学
DOI10.1002/anie.201410293
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000351204600031
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39571
Collection金属有机化学国家重点实验室
Corresponding AuthorHuang Z(黄正)
Affiliation中科院上海有机化学研究所, 金属有机化学国家重点实验室
Recommended Citation
GB/T 7714
Guo L,Ma XC,Fang HQ,et al. A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols[J]. Angew. Chem.-Int. Edit.,2015,54(13):4023-4027.
APA 郭乐,马笑晨,方华权,贾香清,&黄正.(2015).A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols.Angew. Chem.-Int. Edit.,54(13),4023-4027.
MLA 郭乐,et al."A General and Mild Catalytic alpha-Alkylation of Unactivated Esters Using Alcohols".Angew. Chem.-Int. Edit. 54.13(2015):4023-4027.
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