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学科主题: 金属有机化学
题名: Gold-Catalyzed Oxidative Ring Expansion of 2-Alkynyl-1,2-Dihydropyridines or -quinolines: Highly Efficient Synthesis of Functionalized Azepine or Benzazepine Scaffolds
其他题名: 金催化2-炔基-1,2-二氢吡啶或喹啉类衍生物的氧化环扩环反应: 官能团化氮杂唑类化合物的高效合成
作者: Chen M(陈铭); Chen YF(陈宜峰); Sun N(孙宁); Zhao JD(赵继东); Liu YH(刘元红); Li YX(李玉学)
通讯作者: 刘元红 ; 李玉学
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201410056
卷: 54, 期:4, 页:1200-1204
收录类别: SCI
文章类型: 论文
英文摘要: A gold-catalyzed highly regio- and chemoselective oxidative ring expansion of 2-alkynyl-1,2-dihydropyridines and its analogues using pyridine-N-oxide as the oxidant has been developed. Ring expansion proceeds through exclusive 1,2-migration of a vinyl or phenyl group, whereas no 1,2-H and 1,2-N migration take place. The reaction provides an efficient and attractive route to various types of medium-sized azepine derivatives in generally high to excellent yields with a broad functional group tolerance. DFT studies indicate that the reaction proceeds through the formation of a cyclopropyl gold intermediate, and no gold carbene species is involved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000348372900022
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39567
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所, 金属有机化学国家重点实验室

Recommended Citation:
Chen M,Chen YF,Sun N,et al. Gold-Catalyzed Oxidative Ring Expansion of 2-Alkynyl-1,2-Dihydropyridines or -quinolines: Highly Efficient Synthesis of Functionalized Azepine or Benzazepine Scaffolds[J]. Angew. Chem.-Int. Edit.,2015,54(4):1200-1204.
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