SIOC OpenIR  > 生命有机化学国家重点实验室
The versatile low-molecular-weight thiols: Beyond cell protection
其他题名多种多样的小分子硫醇: 功能远不止细胞保护
Wang M(王敏)1; Zhao QF(赵群飞)1; Liu W(刘文)1
2015
发表期刊Bioessays
卷号37期号:12页码:1262-1267
摘要Low-molecular-weight (LMW) thiols are extensively involved in the maintenance of cellular redox potentials and the protection of cells from a variety of reactive chemical and electrophilic species. However, we recently found that the metabolic coupling of two LMW thiols - mycothiol (MSH) and ergothioneine (EGT) - programs the biosynthesis of the anti-infective agent lincomycin A. Remarkably, such a constructive role of the thiols in the biosynthesis of natural products has so far received relatively little attention. We speculate that the unusual thiol EGT might function as a chiral thiolation carrier (for modification) and a novel activator (for glycosylation) of sugar. Additionally, we examine recent evidence for LMW thiols (MSH and others) as sulfur donors of sulfur-containing natural products. Clearly, the LMW thiols have more diverse activities beyond cell protection, and more attention should be paid to the correlation of their functions with thiol-dependent enzymes.
文章类型论文
学科领域生命有机化学
DOI10.1002/bies.201500067
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000365259100003
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39540
专题生命有机化学国家重点实验室
通讯作者Liu W(刘文)
作者单位1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.湖州生物制造创新中心
推荐引用方式
GB/T 7714
Wang M,Zhao QF,Liu W. The versatile low-molecular-weight thiols: Beyond cell protection[J]. Bioessays,2015,37(12):1262-1267.
APA 王敏,赵群飞,&刘文.(2015).The versatile low-molecular-weight thiols: Beyond cell protection.Bioessays,37(12),1262-1267.
MLA 王敏,et al."The versatile low-molecular-weight thiols: Beyond cell protection".Bioessays 37.12(2015):1262-1267.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2015627.pdf(1350KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[王敏]的文章
[赵群飞]的文章
[刘文]的文章
百度学术
百度学术中相似的文章
[王敏]的文章
[赵群飞]的文章
[刘文]的文章
必应学术
必应学术中相似的文章
[王敏]的文章
[赵群飞]的文章
[刘文]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。