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The versatile low-molecular-weight thiols: Beyond cell protection
Alternative Title多种多样的小分子硫醇: 功能远不止细胞保护
Wang M(王敏)1; Zhao QF(赵群飞)1; Liu W(刘文)1
Source PublicationBioessays
AbstractLow-molecular-weight (LMW) thiols are extensively involved in the maintenance of cellular redox potentials and the protection of cells from a variety of reactive chemical and electrophilic species. However, we recently found that the metabolic coupling of two LMW thiols - mycothiol (MSH) and ergothioneine (EGT) - programs the biosynthesis of the anti-infective agent lincomycin A. Remarkably, such a constructive role of the thiols in the biosynthesis of natural products has so far received relatively little attention. We speculate that the unusual thiol EGT might function as a chiral thiolation carrier (for modification) and a novel activator (for glycosylation) of sugar. Additionally, we examine recent evidence for LMW thiols (MSH and others) as sulfur donors of sulfur-containing natural products. Clearly, the LMW thiols have more diverse activities beyond cell protection, and more attention should be paid to the correlation of their functions with thiol-dependent enzymes.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000365259100003
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu W(刘文)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Wang M,Zhao QF,Liu W. The versatile low-molecular-weight thiols: Beyond cell protection[J]. Bioessays,2015,37(12):1262-1267.
APA 王敏,赵群飞,&刘文.(2015).The versatile low-molecular-weight thiols: Beyond cell protection.Bioessays,37(12),1262-1267.
MLA 王敏,et al."The versatile low-molecular-weight thiols: Beyond cell protection".Bioessays 37.12(2015):1262-1267.
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