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学科主题: 生命有机化学
题名: The versatile low-molecular-weight thiols: Beyond cell protection
其他题名: 多种多样的小分子硫醇: 功能远不止细胞保护
作者: Wang M(王敏)1; Zhao QF(赵群飞)1; Liu W(刘文)1
通讯作者: 刘文
刊名: Bioessays
发表日期: 2015
DOI: 10.1002/bies.201500067
卷: 37, 期:12, 页:1262-1267
收录类别: SCI
文章类型: 论文
英文摘要: Low-molecular-weight (LMW) thiols are extensively involved in the maintenance of cellular redox potentials and the protection of cells from a variety of reactive chemical and electrophilic species. However, we recently found that the metabolic coupling of two LMW thiols - mycothiol (MSH) and ergothioneine (EGT) - programs the biosynthesis of the anti-infective agent lincomycin A. Remarkably, such a constructive role of the thiols in the biosynthesis of natural products has so far received relatively little attention. We speculate that the unusual thiol EGT might function as a chiral thiolation carrier (for modification) and a novel activator (for glycosylation) of sugar. Additionally, we examine recent evidence for LMW thiols (MSH and others) as sulfur donors of sulfur-containing natural products. Clearly, the LMW thiols have more diverse activities beyond cell protection, and more attention should be paid to the correlation of their functions with thiol-dependent enzymes.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000365259100003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39540
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.湖州生物制造创新中心

Recommended Citation:
Wang M,Zhao QF,Liu W. The versatile low-molecular-weight thiols: Beyond cell protection[J]. Bioessays,2015,37(12):1262-1267.
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