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Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties
Alternative Title以靶点为导向的设计和生物合成获取药理活性更好的硫链丝菌素结构衍生物
Wang SF(王守峰)1; Zheng QF(郑庆飞)1; Wang JF(王建峰)1; Zhao ZX(赵志雄)1; Li QY(李庆业)1; Yu YS(俞云松)1; Wang RX(王任小)1; Liu W(刘文)1
2015
Source PublicationOrg. Chem. Front.
Volume2Issue:2Pages:106-109
AbstractThiostrepton is a potent archetypal thiopeptide antibiotic. According to its mechanism known to target bacterial ribosome, we show here a rational design upon modeling of this molecule into the ribosome complex and an effective biosynthesis of new thiopeptide antibiotics through regioselective modifications. The resulting derivatives exhibit a series of anticipated and unanticipated pharmaceutical advantages, including improvement in activity against a number of drug-resistant pathogens and in water solubility that has largely affected the clinical use of thiostrepton.
Subtype论文
Subject Area生命有机化学
DOI10.1039/c4qo00288a
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000364443200002
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39537
Collection生命有机化学国家重点实验室
Corresponding AuthorLiu W(刘文)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.浙江大学
3.湖州生物制造创新中心
Recommended Citation
GB/T 7714
Wang SF,Zheng QF,Wang JF,et al. Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties[J]. Org. Chem. Front.,2015,2(2):106-109.
APA 王守峰.,郑庆飞.,王建峰.,赵志雄.,李庆业.,...&刘文.(2015).Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties.Org. Chem. Front.,2(2),106-109.
MLA 王守峰,et al."Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties".Org. Chem. Front. 2.2(2015):106-109.
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