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学科主题: 生命有机化学
题名: Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties
其他题名: 以靶点为导向的设计和生物合成获取药理活性更好的硫链丝菌素结构衍生物
作者: Wang SF(王守峰)1; Zheng QF(郑庆飞)1; Wang JF(王建峰)1; Zhao ZX(赵志雄)1; Li QY(李庆业)1; Yu YS(俞云松)1; Wang RX(王任小)1; Liu W(刘文)1
通讯作者: 刘文
刊名: Org. Chem. Front.
发表日期: 2015
DOI: 10.1039/c4qo00288a
卷: 2, 期:2, 页:106-109
收录类别: SCI
文章类型: 论文
英文摘要: Thiostrepton is a potent archetypal thiopeptide antibiotic. According to its mechanism known to target bacterial ribosome, we show here a rational design upon modeling of this molecule into the ribosome complex and an effective biosynthesis of new thiopeptide antibiotics through regioselective modifications. The resulting derivatives exhibit a series of anticipated and unanticipated pharmaceutical advantages, including improvement in activity against a number of drug-resistant pathogens and in water solubility that has largely affected the clinical use of thiostrepton.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000364443200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39537
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.浙江大学
3.湖州生物制造创新中心

Recommended Citation:
Wang SF,Zheng QF,Wang JF,et al. Target-oriented design and biosynthesis of thiostrepton-derived thiopeptide antibiotics with improved pharmaceutical properties[J]. Org. Chem. Front.,2015,2(2):106-109.
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