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Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
Alternative Title细胞自噬受体蛋白CALCOCO2识别泛素蛋白的分子机制
Xie XQ(谢兴巧)1; Li FX(李发祥)1; Wang YY(王圆圆)1; Wang YL(王颖黎)1; Lin ZJ(林志杰)1; Cheng XF(程小芳)1; Liu JP(刘建平)1; Chen CB(陈昌斌)1; Pan LF(潘李锋)1
Source PublicationAutophagy
AbstractThe autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery; thereby it is required for innate immune defense against a range of infectious pathogens in mammals. However, the mechanistic basis underlying CALCOCO2-mediated specific recognition of ubiqutinated pathogens is still unknown. Here, using biochemical and structural analyses, we demonstrated that the cargo-binding region of CALCOCO2 contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains. In addition to elucidating the specific ubiquitin recognition mechanism of CALCOCO2, the structure of the CALCOCO2 C2H2-type zinc finger in complex with mono-ubiquitin also uncovers a unique zinc finger-binding mode for ubiquitin. Our findings provide mechanistic insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000363867800006
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorPan LF(潘李锋)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.中科院上海有机化学研究所, 生物与化学交叉研究中心
Recommended Citation
GB/T 7714
Xie XQ,Li FX,Wang YY,et al. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2[J]. Autophagy,2015,11(10):1775-1789.
APA 谢兴巧.,李发祥.,王圆圆.,王颖黎.,林志杰.,...&潘李锋.(2015).Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2.Autophagy,11(10),1775-1789.
MLA 谢兴巧,et al."Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2".Autophagy 11.10(2015):1775-1789.
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