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学科主题: 生命有机化学
题名: Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
其他题名: 细胞自噬受体蛋白CALCOCO2识别泛素蛋白的分子机制
作者: Xie XQ(谢兴巧)1; Li FX(李发祥)1; Wang YY(王圆圆)1; Wang YL(王颖黎)1; Lin ZJ(林志杰)1; Cheng XF(程小芳)1; Liu JP(刘建平)1; Chen CB(陈昌斌)1; Pan LF(潘李锋)1
通讯作者: 潘李锋
刊名: Autophagy
发表日期: 2015
DOI: 10.1080/15548627.2015.1082025
卷: 11, 期:10, 页:1775-1789
收录类别: SCI
文章类型: 论文
英文摘要: The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subsequently targeting them to the autophagic machinery; thereby it is required for innate immune defense against a range of infectious pathogens in mammals. However, the mechanistic basis underlying CALCOCO2-mediated specific recognition of ubiqutinated pathogens is still unknown. Here, using biochemical and structural analyses, we demonstrated that the cargo-binding region of CALCOCO2 contains a dynamic unconventional zinc finger as well as a C2H2-type zinc-finger, and only the C2H2-type zinc finger specifically recognizes mono-ubiquitin or poly-ubiquitin chains. In addition to elucidating the specific ubiquitin recognition mechanism of CALCOCO2, the structure of the CALCOCO2 C2H2-type zinc finger in complex with mono-ubiquitin also uncovers a unique zinc finger-binding mode for ubiquitin. Our findings provide mechanistic insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000363867800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39535
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.中科院上海有机化学研究所, 生物与化学交叉研究中心
3.中科院上海上海巴斯德研究所
4.香港科技大学

Recommended Citation:
Xie XQ,Li FX,Wang YY,et al. Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2[J]. Autophagy,2015,11(10):1775-1789.
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