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Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe
Alternative Title硫肽类抗生素通过影响宿主和微生物表现出抑制细胞内病原体的双重作用模式
Zheng QF(郑庆飞)1; Wang QL(王晴岚)1; Wang SF(王守峰)1; Wu JQ(吴杰群)1; Gao Q(高谦)1; Liu W(刘文)1
2015
Source PublicationChem. Biol.
Volume22Issue:8Pages:1002-1007
AbstractThiostrepton (TSR) is an archetypal thiopeptide antibiotic possessing a quinaldic acid (QA) moiety in the side ring system. According to the mechanism of TSR previously known to target bacterial ribosome, we recently designed and biosynthesized several TSR derivatives that varied in QA substitution. Utilizing these thiopeptide antibiotics to treat the intracellular pathogen Mycobacterium marinum, we herein report a novel mode of action of TSRs, which induce ER stress-mediated autophagy to enhance host cell defense. This intracellular response, which is sensitive to the modification of the QA group, serves as an indirect but unignorable mechanism for eliminating intracellular pathogens. TSRs are thus the only type of antibiotics, to our knowledge, with the dual action on both the parasitic bacteria and the infected host cells. The newly observed mechanism of TSRs may inspire the future change in the treatment of intracellular pathogens, by taking host response into account.
Subtype论文
Subject Area生命有机化学
DOI10.1016/j.chembiol.2015.06.019
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000361879200006
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39526
Collection生命有机化学国家重点实验室
Corresponding AuthorGao Q(高谦); Liu W(刘文)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.复旦大学
3.湖州生物制造创新中心
Recommended Citation
GB/T 7714
Zheng QF,Wang QL,Wang SF,et al. Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe[J]. Chem. Biol.,2015,22(8):1002-1007.
APA 郑庆飞,王晴岚,王守峰,吴杰群,高谦,&刘文.(2015).Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe.Chem. Biol.,22(8),1002-1007.
MLA 郑庆飞,et al."Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe".Chem. Biol. 22.8(2015):1002-1007.
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