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学科主题: 生命有机化学
题名: Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe
其他题名: 硫肽类抗生素通过影响宿主和微生物表现出抑制细胞内病原体的双重作用模式
作者: Zheng QF(郑庆飞)1; Wang QL(王晴岚)1; Wang SF(王守峰)1; Wu JQ(吴杰群)1; Gao Q(高谦)1; Liu W(刘文)1
通讯作者: 高谦 ; 刘文
刊名: Chem. Biol.
发表日期: 2015
DOI: 10.1016/j.chembiol.2015.06.019
卷: 22, 期:8, 页:1002-1007
收录类别: SCI
文章类型: 论文
英文摘要: Thiostrepton (TSR) is an archetypal thiopeptide antibiotic possessing a quinaldic acid (QA) moiety in the side ring system. According to the mechanism of TSR previously known to target bacterial ribosome, we recently designed and biosynthesized several TSR derivatives that varied in QA substitution. Utilizing these thiopeptide antibiotics to treat the intracellular pathogen Mycobacterium marinum, we herein report a novel mode of action of TSRs, which induce ER stress-mediated autophagy to enhance host cell defense. This intracellular response, which is sensitive to the modification of the QA group, serves as an indirect but unignorable mechanism for eliminating intracellular pathogens. TSRs are thus the only type of antibiotics, to our knowledge, with the dual action on both the parasitic bacteria and the infected host cells. The newly observed mechanism of TSRs may inspire the future change in the treatment of intracellular pathogens, by taking host response into account.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000361879200006
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39526
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.复旦大学
3.湖州生物制造创新中心

Recommended Citation:
Zheng QF,Wang QL,Wang SF,et al. Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe[J]. Chem. Biol.,2015,22(8):1002-1007.
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