SIOC OpenIR  > 生命有机化学国家重点实验室
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
其他题名分子伴侣介导的自噬降解HK2蛋白会引起细胞代谢灾难和细胞死亡
XIA HONGGUANG1; NAJAFOV AYAZ1; GENG JIEFEI1; GALANACOSTA LORENA1; HAN XUEMEI1; GUO YUAN1; SHAN BING1; ZHANG YAOYANG1; NORBERG ERIK1; ZHANG TAO1; PAN LIFENG1; LIU JUNLI1; COLOFF JONATHAN L1; OFENGEIM DIMITRY1; ZHU HONG1; WU KEJIA1; CAI YU1; YATES JOHN R1; ZHU ZHENGJIANG1; Yuan JY(袁钧瑛)1; VAKIFAHMETOGLUNORBERG HELIN1
2015
发表期刊J. Cell Biol.
卷号210期号:5页码:705-716
摘要Hexokinase II (HK2), a key enzyme involved in glucose metabolism, is regulated by growth factor signaling and is required for initiation and maintenance of tumors. Here we show that metabolic stress triggered by perturbation of receptor tyrosine kinase FLT3 in non-acute myeloid leukemia cells sensitizes cancer cells to autophagy inhibition and leads to excessive activation of chaperone-mediated autophagy (CMA). Our data demonstrate that FLT3 is an important sensor of cellular nutritional state and elucidate the role and molecular mechanism of CMA in metabolic regulation and mediating cancer cell death. Importantly, our proteome analysis revealed that HK2 is a CMA substrate and that its degradation by CMA is regulated by glucose availability. We reveal a new mechanism by which excessive activation of CMA may be exploited pharmacologically to eliminate cancer cells by inhibiting both FLT3 and autophagy. Our study delineates a novel pharmacological strategy to promote the degradation of HK2 in cancer cells.
文章类型论文
学科领域生命有机化学
DOI10.1083/jcb.201503044
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000360685600006
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39525
专题生命有机化学国家重点实验室
通讯作者Yuan JY(袁钧瑛)
作者单位1.美国哈佛大学
2.瑞典卡罗林斯卡学院
3.美国斯克利普斯研究所
4.中科院上海有机化学研究所, 生物与化学交叉研究中心
推荐引用方式
GB/T 7714
XIA HONGGUANG,NAJAFOV AYAZ,GENG JIEFEI,et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death[J]. J. Cell Biol.,2015,210(5):705-716.
APA XIA HONGGUANG.,NAJAFOV AYAZ.,GENG JIEFEI.,GALANACOSTA LORENA.,HAN XUEMEI.,...&VAKIFAHMETOGLUNORBERG HELIN.(2015).Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.J. Cell Biol.,210(5),705-716.
MLA XIA HONGGUANG,et al."Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death".J. Cell Biol. 210.5(2015):705-716.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2015465.pdf(3915KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[XIA HONGGUANG]的文章
[NAJAFOV AYAZ]的文章
[GENG JIEFEI]的文章
百度学术
百度学术中相似的文章
[XIA HONGGUANG]的文章
[NAJAFOV AYAZ]的文章
[GENG JIEFEI]的文章
必应学术
必应学术中相似的文章
[XIA HONGGUANG]的文章
[NAJAFOV AYAZ]的文章
[GENG JIEFEI]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。