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O-Glycosylation methods in the total synthesis of complex natural glycosides
Alternative Title氧-糖苷化在天然糖苷类化合物合成中的应用
Yang Y(杨友)1; Zhang XH(张夏衡)1; Yu B(俞飚)1
Source PublicationNat. Prod. Rep.
AbstractThe total syntheses of 33 complex natural O-glycosides, such as the glycosides of macrocyclic lactones/lactams, enediynes, angucyclines, and anthracyclines, are highlighted, with a major focus being placed on the O-glycosylation reactions which connect the saccharides and the aglycones. These successful O-glycosylation reactions employ such donors as glycosyl bromides, fluorides, iodides, trichloroacetimidates, N-phenyl trifluoroacetimidates, thioglycosides, sulfoxides, heteroaryl thioglycosides, 1-hydroxyl sugars, 1-O-acetates, and ortho-alkynylbenzoates. Each synthesis is depicted starting from the O-glycosylation of the aglycone (or its precursor); the glycosylation conditions and outcomes (yields and stereoselectivities) are discussed, and the subsequent transformations toward the final target, including the elongation of the glycan, the elaboration of the aglycone, and the protecting group manipulations are also given in detail.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000360115000004
Citation statistics
Cited Times:73[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYang Y(杨友); Yu B(俞飚)
2.中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Yang Y,Zhang XH,Yu B. O-Glycosylation methods in the total synthesis of complex natural glycosides[J]. Nat. Prod. Rep.,2015,32(9):1331-1355.
APA 杨友,张夏衡,&俞飚.(2015).O-Glycosylation methods in the total synthesis of complex natural glycosides.Nat. Prod. Rep.,32(9),1331-1355.
MLA 杨友,et al."O-Glycosylation methods in the total synthesis of complex natural glycosides".Nat. Prod. Rep. 32.9(2015):1331-1355.
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