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学科主题: 生命有机化学
题名: The SARP Family Regulator Txn9 and Two-Component Response Regulator Txn11 are Key Activators for Trioxacarcin Biosynthesis in Streptomyces bottropensis
其他题名: SARP家族调控蛋白Txn9和双组份调控蛋白Txn11是三欣卡辛生物合成中的正调控因子
作者: Yang K(杨魁)1; Qi LH(漆丽华)1; Zhang M(张媚)1; Hou XF(侯现锋)1; Pan HX(潘海学)1; Tang GL(唐功利)1; Wang W(王伟)1; Yuan H(袁华)1
通讯作者: 王伟 ; 袁华
刊名: Curr. Microbiol.
发表日期: 2015
DOI: 10.1007/s00284-015-0868-9
卷: 71, 期:4, 页:458-464
收录类别: SCI
文章类型: 论文
英文摘要: Trioxacarcin A is a polyoxygenated, structurally complex antibiotic produced by Streptomyces spp., which possesses high anti-bacterial, anti-malaria, and anti-tumor activities. The trioxacarcin biosynthetic pathway involves type II polyketide synthases (PKSs) with l-isoleucine as a unique starter unit, as well as many complex post-PKS tailoring enzymes and resistance and regulatory proteins. In this work, two regulatory genes, txn9 coding for a Streptomyces antibiotic regulatory protein family regulator and txn11 for a two-component response regulator, were revealed to be absolutely required for trioxacarcin production by individually inactivating all the six annotated regulatory genes in the txn cluster. Complementation assay suggested that these two activators do not have a regulatory cascade relationship. Moreover, transcriptional analysis showed that they activate 15 of the 28 txn operons, indicating that a complicated regulatory network is involved in the trioxacarcin production. Information gained from this study may be useful for improving the production of the highly potent trioxacarcin A.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000359807900005
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39518
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.上海应用技术学院
2.中科院上海有机化学研究所, 生命有机化学国家重点实验室

Recommended Citation:
Yang K,Qi LH,Zhang M,et al. The SARP Family Regulator Txn9 and Two-Component Response Regulator Txn11 are Key Activators for Trioxacarcin Biosynthesis in Streptomyces bottropensis[J]. Curr. Microbiol.,2015,71(4):458-464.
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