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Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions
Alternative Title高价碘促进的脱羧炔酮化反应在温和光催化条件下进行
Huang HC(黄汉初); Zhang GJ(张国晋); Chen YY(陈以昀)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:27Pages:7872-7876
AbstractA combination of hypervalent iodine(III) reagents (HIR) and photoredox catalysis with visible light has enabled chemoselective decarboxylative ynonylation to construct ynones, ynamides, and ynoates. This ynonylation occurs effectively under mild reaction conditions at room temperature and on substrates with various sensitive and reactive functional groups. The reaction represents the first HIR/photoredox dual catalysis to form acyl radicals from -ketoacids, followed by an unprecedented acyl radical addition to HIR-bound alkynes. Its efficient construction of an mGlu5 receptor inhibitor under neutral aqueous conditions suggests future visible-light-induced biological applications.
Subtype论文
Subject Area生命有机化学
DOI10.1002/anie.201502369
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000356886600024
Citation statistics
Cited Times:102[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39510
Collection生命有机化学国家重点实验室
Corresponding AuthorChen YY(陈以昀)
Affiliation中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Huang HC,Zhang GJ,Chen YY. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions[J]. Angew. Chem.-Int. Edit.,2015,54(27):7872-7876.
APA 黄汉初,张国晋,&陈以昀.(2015).Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions.Angew. Chem.-Int. Edit.,54(27),7872-7876.
MLA 黄汉初,et al."Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions".Angew. Chem.-Int. Edit. 54.27(2015):7872-7876.
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