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学科主题: 生命有机化学
题名: Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions
其他题名: 高价碘促进的脱羧炔酮化反应在温和光催化条件下进行
作者: Huang HC(黄汉初); Zhang GJ(张国晋); Chen YY(陈以昀)
通讯作者: 陈以昀
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201502369
卷: 54, 期:27, 页:7872-7876
收录类别: SCI
文章类型: 论文
英文摘要: A combination of hypervalent iodine(III) reagents (HIR) and photoredox catalysis with visible light has enabled chemoselective decarboxylative ynonylation to construct ynones, ynamides, and ynoates. This ynonylation occurs effectively under mild reaction conditions at room temperature and on substrates with various sensitive and reactive functional groups. The reaction represents the first HIR/photoredox dual catalysis to form acyl radicals from -ketoacids, followed by an unprecedented acyl radical addition to HIR-bound alkynes. Its efficient construction of an mGlu5 receptor inhibitor under neutral aqueous conditions suggests future visible-light-induced biological applications.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000356886600024
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39510
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所, 生命有机化学国家重点实验室

Recommended Citation:
Huang HC,Zhang GJ,Chen YY. Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions[J]. Angew. Chem.-Int. Edit.,2015,54(27):7872-7876.
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