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Structure-activity relationship study of E6 as a novel necroptosis inducer
Alternative Title程序性细胞坏死诱导剂E6的构效关系研究
Mou JF(牟剑锋)1; PARK ANN1; Cai Y(蔡俞)1; Yuan JY(袁钧瑛)1; Yuan CY(袁承业)1
Source PublicationBioorg. Med. Chem. Lett.
AbstractNecroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000356101700035
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Document Type期刊论文
Corresponding AuthorYuan CY(袁承业)
Affiliation1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Mou JF,PARK ANN,Cai Y,et al. Structure-activity relationship study of E6 as a novel necroptosis inducer[J]. Bioorg. Med. Chem. Lett.,2015,25(15):3057-3061.
APA 牟剑锋,PARK ANN,蔡俞,袁钧瑛,&袁承业.(2015).Structure-activity relationship study of E6 as a novel necroptosis inducer.Bioorg. Med. Chem. Lett.,25(15),3057-3061.
MLA 牟剑锋,et al."Structure-activity relationship study of E6 as a novel necroptosis inducer".Bioorg. Med. Chem. Lett. 25.15(2015):3057-3061.
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