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学科主题: 生命有机化学
题名: Structure-activity relationship study of E6 as a novel necroptosis inducer
其他题名: 程序性细胞坏死诱导剂E6的构效关系研究
作者: Mou JF(牟剑锋)1; PARK ANN1; Cai Y(蔡俞)1; Yuan JY(袁钧瑛)1; Yuan CY(袁承业)1
通讯作者: 袁承业
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2015
DOI: 10.1016/j.bmcl.2015.04.038
卷: 25, 期:15, 页:3057-3061
收录类别: SCI
文章类型: 论文
英文摘要: Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000356101700035
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39508
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室
2.美国哈佛大学

Recommended Citation:
Mou JF,PARK ANN,Cai Y,et al. Structure-activity relationship study of E6 as a novel necroptosis inducer[J]. Bioorg. Med. Chem. Lett.,2015,25(15):3057-3061.
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