| Structure-activity relationship study of E6 as a novel necroptosis inducer | |
| Alternative Title | 程序性细胞坏死诱导剂E6的构效关系研究 |
| Mou JF(牟剑锋)1; PARK ANN1; Cai Y(蔡俞)1; Yuan JY(袁钧瑛)1; Yuan CY(袁承业)1 | |
| 2015 | |
| Source Publication | Bioorg. Med. Chem. Lett.
 |
| Volume | 25Issue:15Pages:3057-3061 |
| Abstract | Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved. |
| Subtype | 论文 |
| Subject Area | 生命有机化学 |
| DOI | 10.1016/j.bmcl.2015.04.038 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000356101700035 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sioc.ac.cn/handle/331003/39508 |
| Collection | 生命有机化学国家重点实验室 |
| Corresponding Author | Yuan CY(袁承业) |
| Affiliation | 1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.美国哈佛大学 |
| Recommended Citation GB/T 7714 | Mou JF,PARK ANN,Cai Y,et al. Structure-activity relationship study of E6 as a novel necroptosis inducer[J]. Bioorg. Med. Chem. Lett.,2015,25(15):3057-3061. |
| APA | 牟剑锋,PARK ANN,蔡俞,袁钧瑛,&袁承业.(2015).Structure-activity relationship study of E6 as a novel necroptosis inducer.Bioorg. Med. Chem. Lett.,25(15),3057-3061. |
| MLA | 牟剑锋,et al."Structure-activity relationship study of E6 as a novel necroptosis inducer".Bioorg. Med. Chem. Lett. 25.15(2015):3057-3061. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2015298.pdf（1515KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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