Structure-activity relationship study of E6 as a novel necroptosis inducer

doi:10.1016/j.bmcl.2015.04.038

	Structure-activity relationship study of E6 as a novel necroptosis inducer
其他题名	程序性细胞坏死诱导剂E6的构效关系研究
	Mou JF(牟剑锋)1; PARK ANN 1; Cai Y(蔡俞)1; Yuan JY(袁钧瑛)1; Yuan CY(袁承业)1
	2015
发表期刊	Bioorg. Med. Chem. Lett.
卷号	25 期号:15 页码:3057-3061
摘要	Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved.
文章类型	论文
学科领域	生命有机化学
DOI	10.1016/j.bmcl.2015.04.038
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000356101700035
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sioc.ac.cn/handle/331003/39508
专题	生命有机化学国家重点实验室
通讯作者	Yuan CY(袁承业)
作者单位	1.中科院上海有机化学研究所, 生命有机化学国家重点实验室 2.美国哈佛大学
推荐引用方式 GB/T 7714	Mou JF,PARK ANN,Cai Y,et al. Structure-activity relationship study of E6 as a novel necroptosis inducer[J]. Bioorg. Med. Chem. Lett.,2015,25(15):3057-3061.
APA	牟剑锋,PARK ANN,蔡俞,袁钧瑛,&袁承业.(2015).Structure-activity relationship study of E6 as a novel necroptosis inducer.Bioorg. Med. Chem. Lett.,25(15),3057-3061.
MLA	牟剑锋,et al."Structure-activity relationship study of E6 as a novel necroptosis inducer".Bioorg. Med. Chem. Lett. 25.15(2015):3057-3061.

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