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A Modular Approach to the Total Synthesis of Tunicamycins
Alternative Title衣霉素的模块化全合成
Li JK(李家昆); Yu B(俞飚)
2015
Source PublicationAngew. Chem.-Int. Edit.
Volume54Issue:22Pages:6618-6621
AbstractThe tunicamycins constitute a delicate mimic of the bisubstrate intermediates of N-acetyl-D-hexosamine-1-phosphate translocases and thus inhibit bacterial cell-wall synthesis and the Nglycosylation of eukaryotic proteins. An efficient approach to the synthesis of this unique type of nucleoside antibiotics is now reported and features the assembly of five modules in a highly stereoselective and robust manner. A Mukaiyama aldol reaction, intramolecular acetal formation, gold(I)-catalyzed O and Nglycosylation, and final Nacylation were used as the key steps.
Subtype论文
Subject Area生命有机化学
DOI10.1002/anie.201501890
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000355229800041
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39506
Collection生命有机化学国家重点实验室
Corresponding AuthorYu B(俞飚)
Affiliation中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Li JK,Yu B. A Modular Approach to the Total Synthesis of Tunicamycins[J]. Angew. Chem.-Int. Edit.,2015,54(22):6618-6621.
APA 李家昆,&俞飚.(2015).A Modular Approach to the Total Synthesis of Tunicamycins.Angew. Chem.-Int. Edit.,54(22),6618-6621.
MLA 李家昆,et al."A Modular Approach to the Total Synthesis of Tunicamycins".Angew. Chem.-Int. Edit. 54.22(2015):6618-6621.
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