中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: A Modular Approach to the Total Synthesis of Tunicamycins
其他题名: 衣霉素的模块化全合成
作者: Li JK(李家昆); Yu B(俞飚)
通讯作者: 俞飚
刊名: Angew. Chem.-Int. Edit.
发表日期: 2015
DOI: 10.1002/anie.201501890
卷: 54, 期:22, 页:6618-6621
收录类别: SCI
文章类型: 论文
英文摘要: The tunicamycins constitute a delicate mimic of the bisubstrate intermediates of N-acetyl-D-hexosamine-1-phosphate translocases and thus inhibit bacterial cell-wall synthesis and the Nglycosylation of eukaryotic proteins. An efficient approach to the synthesis of this unique type of nucleoside antibiotics is now reported and features the assembly of five modules in a highly stereoselective and robust manner. A Mukaiyama aldol reaction, intramolecular acetal formation, gold(I)-catalyzed O and Nglycosylation, and final Nacylation were used as the key steps.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000355229800041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39506
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2015273.pdf(657KB)期刊论文作者接受稿开放获取View Download

作者单位: 中科院上海有机化学研究所, 生命有机化学国家重点实验室

Recommended Citation:
Li JK,Yu B. A Modular Approach to the Total Synthesis of Tunicamycins[J]. Angew. Chem.-Int. Edit.,2015,54(22):6618-6621.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[李家昆]'s Articles
[俞飚]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[李家昆]‘s Articles
[俞飚]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2015273.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace