SIOC OpenIR  > 生命有机化学国家重点实验室
A Modular Approach to the Total Synthesis of Tunicamycins
Alternative Title衣霉素的模块化全合成
Li JK(李家昆); Yu B(俞飚)
Source PublicationAngew. Chem.-Int. Edit.
AbstractThe tunicamycins constitute a delicate mimic of the bisubstrate intermediates of N-acetyl-D-hexosamine-1-phosphate translocases and thus inhibit bacterial cell-wall synthesis and the Nglycosylation of eukaryotic proteins. An efficient approach to the synthesis of this unique type of nucleoside antibiotics is now reported and features the assembly of five modules in a highly stereoselective and robust manner. A Mukaiyama aldol reaction, intramolecular acetal formation, gold(I)-catalyzed O and Nglycosylation, and final Nacylation were used as the key steps.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000355229800041
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYu B(俞飚)
Affiliation中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Li JK,Yu B. A Modular Approach to the Total Synthesis of Tunicamycins[J]. Angew. Chem.-Int. Edit.,2015,54(22):6618-6621.
APA 李家昆,&俞飚.(2015).A Modular Approach to the Total Synthesis of Tunicamycins.Angew. Chem.-Int. Edit.,54(22),6618-6621.
MLA 李家昆,et al."A Modular Approach to the Total Synthesis of Tunicamycins".Angew. Chem.-Int. Edit. 54.22(2015):6618-6621.
Files in This Item:
File Name/Size DocType Version Access License
2015273.pdf(657KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[李家昆]'s Articles
[俞飚]'s Articles
Baidu academic
Similar articles in Baidu academic
[李家昆]'s Articles
[俞飚]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[李家昆]'s Articles
[俞飚]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.