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Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
Alternative TitleModification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
XU DAICHAO1; ZHANG TAO1; XIAO JUAN1; ZHU KEZHOU1; WEI RAN1; WU ZHEMING1; MENG HUYAN1; LI YING1; Yuan JY(袁钧瑛)1
2015
Source PublicationAutophagy
Volume11Issue:4Pages:617-628
AbstractISG15 (ISG15 ubiquitin-like modifier), a ubiquitin-like protein, is one of the major type I IFN (interferon) effector systems. ISG15 can be conjugated to target proteins (ISGylation) via the stepwise action of E1, E2, and E3 enzymes. Conjugated ISG15 can be removed (deISGylated) from target proteins by USP18 (ubiquitin-specific peptidase 18). Here we investigated the role of deISGylation by USP18 in regulating autophagy and EGFR degradation in cells treated with type I IFNs. We show that type I IFN induced expression of ISG15 leads to ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 which competes with Lys63 ubiquitination of BECN1. We demonstrate that ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 serve an important role in negative regulation of intracellular processes including autophagy and EGFR degradation that are critically dependent upon the activity of class III PtdIns 3-kinase. Our studies provide fundamental new mechanistic insights into the innate immunity response implemented by type I IFNs.
Subtype论文
Subject Area生命有机化学
DOI10.1080/15548627.2015.1023982
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000354185500005
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39502
Collection生命有机化学国家重点实验室
Affiliation1.中科院上海有机化学研究所, 生物与化学交叉研究中心
2.美国哈佛大学
Recommended Citation
GB/T 7714
XU DAICHAO,ZHANG TAO,XIAO JUAN,et al. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon[J]. Autophagy,2015,11(4):617-628.
APA XU DAICHAO.,ZHANG TAO.,XIAO JUAN.,ZHU KEZHOU.,WEI RAN.,...&袁钧瑛.(2015).Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.Autophagy,11(4),617-628.
MLA XU DAICHAO,et al."Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon".Autophagy 11.4(2015):617-628.
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