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Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
其他题名Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
XU DAICHAO1; ZHANG TAO1; XIAO JUAN1; ZHU KEZHOU1; WEI RAN1; WU ZHEMING1; MENG HUYAN1; LI YING1; Yuan JY(袁钧瑛)1
2015
发表期刊Autophagy
卷号11期号:4页码:617-628
摘要ISG15 (ISG15 ubiquitin-like modifier), a ubiquitin-like protein, is one of the major type I IFN (interferon) effector systems. ISG15 can be conjugated to target proteins (ISGylation) via the stepwise action of E1, E2, and E3 enzymes. Conjugated ISG15 can be removed (deISGylated) from target proteins by USP18 (ubiquitin-specific peptidase 18). Here we investigated the role of deISGylation by USP18 in regulating autophagy and EGFR degradation in cells treated with type I IFNs. We show that type I IFN induced expression of ISG15 leads to ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 which competes with Lys63 ubiquitination of BECN1. We demonstrate that ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 serve an important role in negative regulation of intracellular processes including autophagy and EGFR degradation that are critically dependent upon the activity of class III PtdIns 3-kinase. Our studies provide fundamental new mechanistic insights into the innate immunity response implemented by type I IFNs.
文章类型论文
学科领域生命有机化学
DOI10.1080/15548627.2015.1023982
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收录类别SCI
语种英语
WOS记录号WOS:000354185500005
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39502
专题生命有机化学国家重点实验室
作者单位1.中科院上海有机化学研究所, 生物与化学交叉研究中心
2.美国哈佛大学
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XU DAICHAO,ZHANG TAO,XIAO JUAN,et al. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon[J]. Autophagy,2015,11(4):617-628.
APA XU DAICHAO.,ZHANG TAO.,XIAO JUAN.,ZHU KEZHOU.,WEI RAN.,...&袁钧瑛.(2015).Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.Autophagy,11(4),617-628.
MLA XU DAICHAO,et al."Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon".Autophagy 11.4(2015):617-628.
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