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学科主题: 生命有机化学
题名: Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
其他题名: Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
作者: XU DAICHAO1; ZHANG TAO1; XIAO JUAN1; ZHU KEZHOU1; WEI RAN1; WU ZHEMING1; MENG HUYAN1; LI YING1; Yuan JY(袁钧瑛)1
刊名: Autophagy
发表日期: 2015
DOI: 10.1080/15548627.2015.1023982
卷: 11, 期:4, 页:617-628
收录类别: SCI
文章类型: 论文
英文摘要: ISG15 (ISG15 ubiquitin-like modifier), a ubiquitin-like protein, is one of the major type I IFN (interferon) effector systems. ISG15 can be conjugated to target proteins (ISGylation) via the stepwise action of E1, E2, and E3 enzymes. Conjugated ISG15 can be removed (deISGylated) from target proteins by USP18 (ubiquitin-specific peptidase 18). Here we investigated the role of deISGylation by USP18 in regulating autophagy and EGFR degradation in cells treated with type I IFNs. We show that type I IFN induced expression of ISG15 leads to ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 which competes with Lys63 ubiquitination of BECN1. We demonstrate that ISGylation of BECN1 at Lys117, as well as Lys263, Lys265, and Lys266 serve an important role in negative regulation of intracellular processes including autophagy and EGFR degradation that are critically dependent upon the activity of class III PtdIns 3-kinase. Our studies provide fundamental new mechanistic insights into the innate immunity response implemented by type I IFNs.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000354185500005
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39502
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生物与化学交叉研究中心
2.美国哈佛大学

Recommended Citation:
XU DAICHAO,ZHANG TAO,XIAO JUAN,et al. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon[J]. Autophagy,2015,11(4):617-628.
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