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Synthesis of the tetracyclic core of chlorospermines
Alternative TitleSynthesis of the tetracyclic core of chlorospermines
Wan M(万明)1; Yao M(姚明)1; Gong JY(宫君宇)1; Yang P(杨鹏)1; Liu H(刘华)1; Li A(李昂)1
Source PublicationChin. Chem. Lett.
AbstractChlorospermines A and B are biologically interesting acridone natural products and recently isolated from Glycosmis chlorosperrna. We report here a convergent approach to construct the tetracyclic core of the natural products. The two fragments are assembled together through Sonogashira coupling, and a cis-triene intermediate was prepared by using hydrosilylation/desilylation. A 6 pi-electrocyclization/aromatization sequence served as the key step of the synthesis, which formed the tetrasubstituted arene motif in one pot. (C) 2015 Hua Liu and Ang Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.
Subject Area生命有机化学
Indexed BySCI
WOS IDWOS:000353089000002
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Document Type期刊论文
Corresponding AuthorLiu H(刘华); Li A(李昂)
2.中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Wan M,Yao M,Gong JY,et al. Synthesis of the tetracyclic core of chlorospermines[J]. Chin. Chem. Lett.,2015,26(3):272-276.
APA 万明,姚明,宫君宇,杨鹏,刘华,&李昂.(2015).Synthesis of the tetracyclic core of chlorospermines.Chin. Chem. Lett.,26(3),272-276.
MLA 万明,et al."Synthesis of the tetracyclic core of chlorospermines".Chin. Chem. Lett. 26.3(2015):272-276.
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