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学科主题: 生命有机化学
题名: Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA
其他题名: 淀粉样多肽纳米片层的设计及其在病毒侵染细胞中的应用
作者: Dai B(代彬)1; Li D(李丹)1; Xi WH(郗文辉)1; Luo F(罗芳)1; Zhang X(张祥)1; Zou M(邹曼)1; Hu J(胡均)1; Wang WY(王文元)1; Wei GH(韦广红)1; Zhang Y(张益)1; Liu C(刘聪)1
通讯作者: 韦广红 ; 张益 ; 刘聪
刊名: Proc. Natl. Acad. Sci. U. S. A.
发表日期: 2015
DOI: 10.1073/pnas.1416690112
卷: 112, 期:10, 页:2996-3001
收录类别: SCI
文章类型: 论文
英文摘要: Using and engineering amyloid as nanomaterials are blossoming trends in bionanotechnology. Here, we show our discovery of an amyloid structure, termed "amyloid-like nanosheet," formed by a key amyloid-forming segment of Alzheimer's A beta. Combining multiple biophysical and computational approaches, we proposed a structural model for the nanosheet that is formed by stacking the amyloid fibril spines perpendicular to the fibril axis. We further used the nanosheet for laboratorial retroviral transduction enhancement and directly visualized the presence of virus on the nanosheet surface by electron microscopy. Furthermore, based on our structural model, we designed nanosheet-forming peptides with different functionalities, elucidating the potential of rational design for amyloid-based materials with novel architecture and function.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000350646500037
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39488
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所, 生物与化学交叉研究中心
2.复旦大学
3.中科院上海应用物理所
4.中科院上海生命科学研究院上海蛋白质中心

Recommended Citation:
Dai B,Li D,Xi WH,et al. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA[J]. Proc. Natl. Acad. Sci. U. S. A.,2015,112(10):2996-3001.
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