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Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA
Alternative Title淀粉样多肽纳米片层的设计及其在病毒侵染细胞中的应用
Dai B(代彬)1; Li D(李丹)1; Xi WH(郗文辉)1; Luo F(罗芳)1; Zhang X(张祥)1; Zou M(邹曼)1; Hu J(胡均)1; Wang WY(王文元)1; Wei GH(韦广红)1; Zhang Y(张益)1; Liu C(刘聪)1
2015
Source PublicationProc. Natl. Acad. Sci. U. S. A.
Volume112Issue:10Pages:2996-3001
AbstractUsing and engineering amyloid as nanomaterials are blossoming trends in bionanotechnology. Here, we show our discovery of an amyloid structure, termed "amyloid-like nanosheet," formed by a key amyloid-forming segment of Alzheimer's A beta. Combining multiple biophysical and computational approaches, we proposed a structural model for the nanosheet that is formed by stacking the amyloid fibril spines perpendicular to the fibril axis. We further used the nanosheet for laboratorial retroviral transduction enhancement and directly visualized the presence of virus on the nanosheet surface by electron microscopy. Furthermore, based on our structural model, we designed nanosheet-forming peptides with different functionalities, elucidating the potential of rational design for amyloid-based materials with novel architecture and function.
Subtype论文
Subject Area生命有机化学
DOI10.1073/pnas.1416690112
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000350646500037
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39488
Collection生命有机化学国家重点实验室
Corresponding AuthorWei GH(韦广红); Zhang Y(张益); Liu C(刘聪)
Affiliation1.中科院上海有机化学研究所, 生物与化学交叉研究中心
2.复旦大学
3.中科院上海应用物理所
4.中科院上海生命科学研究院上海蛋白质中心
Recommended Citation
GB/T 7714
Dai B,Li D,Xi WH,et al. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA[J]. Proc. Natl. Acad. Sci. U. S. A.,2015,112(10):2996-3001.
APA 代彬.,李丹.,郗文辉.,罗芳.,张祥.,...&刘聪.(2015).Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA.Proc. Natl. Acad. Sci. U. S. A.,112(10),2996-3001.
MLA 代彬,et al."Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier AMERICA".Proc. Natl. Acad. Sci. U. S. A. 112.10(2015):2996-3001.
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