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Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
Alternative TitleElucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
Li HX(李慧贤)1; Sun Y(孙域)1; Zhang QB(张庆波)1; ZHU YIGUANG1; LI SHUMING1; Li A(李昂)1; Zhang ZS(张长生)1
2015
Source PublicationOrg. Lett.
Volume17Issue:2Pages:306-309
AbstractIndolosesquiterpene xiamycin A features a pentacyclic core structure. The chemical synthesis of two key precursors, 3-farnesylindole and 3-(epoxyfarnesyl)-indole, allowed elucidation of the enzymatic cascades forming the pentacyclic ring system of xiamycin A by XiaO-catalyzed epoxidation and the membrane protein XiaH-catalyzed terpene cyclization. The substrate flexibility of XiaI, an indole oxygenase for assembly of the central ring, was also demonstrated.
Subtype论文
Subject Area生命有机化学
DOI10.1021/ol503399b
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000348331800035
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Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39487
Collection生命有机化学国家重点实验室
Corresponding AuthorZhang ZS(张长生)
Affiliation1.中科院南海海洋研究所
2.中科院上海有机化学研究所, 生命有机化学国家重点实验室
3.德国马堡大学
Recommended Citation
GB/T 7714
Li HX,Sun Y,Zhang QB,et al. Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations[J]. Org. Lett.,2015,17(2):306-309.
APA 李慧贤.,孙域.,张庆波.,ZHU YIGUANG.,LI SHUMING.,...&张长生.(2015).Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations.Org. Lett.,17(2),306-309.
MLA 李慧贤,et al."Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations".Org. Lett. 17.2(2015):306-309.
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