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学科主题: 生命有机化学
题名: Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
其他题名: Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
作者: Li HX(李慧贤)1; Sun Y(孙域)1; Zhang QB(张庆波)1; ZHU YIGUANG1; LI SHUMING1; Li A(李昂)1; Zhang ZS(张长生)1
通讯作者: 张长生
刊名: Org. Lett.
发表日期: 2015
DOI: 10.1021/ol503399b
卷: 17, 期:2, 页:306-309
收录类别: SCI
文章类型: 论文
英文摘要: Indolosesquiterpene xiamycin A features a pentacyclic core structure. The chemical synthesis of two key precursors, 3-farnesylindole and 3-(epoxyfarnesyl)-indole, allowed elucidation of the enzymatic cascades forming the pentacyclic ring system of xiamycin A by XiaO-catalyzed epoxidation and the membrane protein XiaH-catalyzed terpene cyclization. The substrate flexibility of XiaI, an indole oxygenase for assembly of the central ring, was also demonstrated.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000348331800035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39487
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院南海海洋研究所
2.中科院上海有机化学研究所, 生命有机化学国家重点实验室
3.德国马堡大学

Recommended Citation:
Li HX,Sun Y,Zhang QB,et al. Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations[J]. Org. Lett.,2015,17(2):306-309.
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