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Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers
Alternative TitleStereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers
Qiu HB(邱海波); Qian WJ(钱文建); Yu SM(于顺明); Yao ZJ(姚祝军)
2015
Source PublicationTetrahedron
Volume71Issue:2Pages:370-380
AbstractChlorofusin (1), one of few natural antagonists against p53-MDM2 interactions, is a naturally biogenetic hybrid composed of a 27-membered nonacyclopeptide and a unique chromophore through the hydrocarbon linkage with ornithine. In this article, we describe our recent achievement, in details, of developing a convenient stereodivergent route for parallel total synthesis of chlorofusin (1) and its all seven chromophore diastereomers (1a-1g) in enantiopure forms, starting from a common racemic azaphilone precursor 10. The newly developed total synthesis shows the great advantages of economy, scalability, stable intermediates, high yields, ease of HPLC-free operations and reduplication. (C) 2014 Elsevier Ltd. All rights reserved.
Subtype论文
Subject Area生命有机化学
DOI10.1016/j.tet.2014.10.062
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000348083200019
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39479
Collection生命有机化学国家重点实验室
Corresponding AuthorYao ZJ(姚祝军)
Affiliation中科院上海有机化学研究所, 生命有机化学国家重点实验室
Recommended Citation
GB/T 7714
Qiu HB,Qian WJ,Yu SM,et al. Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers[J]. Tetrahedron,2015,71(2):370-380.
APA 邱海波,钱文建,于顺明,&姚祝军.(2015).Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers.Tetrahedron,71(2),370-380.
MLA 邱海波,et al."Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers".Tetrahedron 71.2(2015):370-380.
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