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学科主题: 生命有机化学
题名: Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers
其他题名: Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers
作者: Qiu HB(邱海波); Qian WJ(钱文建); Yu SM(于顺明); Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron
发表日期: 2015
DOI: 10.1016/j.tet.2014.10.062
卷: 71, 期:2, 页:370-380
收录类别: SCI
文章类型: 论文
英文摘要: Chlorofusin (1), one of few natural antagonists against p53-MDM2 interactions, is a naturally biogenetic hybrid composed of a 27-membered nonacyclopeptide and a unique chromophore through the hydrocarbon linkage with ornithine. In this article, we describe our recent achievement, in details, of developing a convenient stereodivergent route for parallel total synthesis of chlorofusin (1) and its all seven chromophore diastereomers (1a-1g) in enantiopure forms, starting from a common racemic azaphilone precursor 10. The newly developed total synthesis shows the great advantages of economy, scalability, stable intermediates, high yields, ease of HPLC-free operations and reduplication. (C) 2014 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000348083200019
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39479
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所, 生命有机化学国家重点实验室

Recommended Citation:
Qiu HB,Qian WJ,Yu SM,et al. Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers[J]. Tetrahedron,2015,71(2):370-380.
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