SIOC OpenIR  > 上海有机化学研究所
Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery
Alternative Title为靶向药物传递的适体偶联药物的自动模块化合成
Wang RW(王若文)1; ZHU GUIZHI1; MEI LEI1; XIE YAN1; MA HAIBIN1; YE MAO1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
2014
Source PublicationJ. Am. Chem. Soc.
Volume136Issue:7Pages:2731-2734
AbstractAptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis, which is a phosphoramdite containing an anticancer drug moiety and a photocleavable linker. Using this module, we have realized automated and modular synthesis of ApDCs, and multiple drugs were efficiently incorporated into ApDCs at predesigned positions. The ApDCs not only recognize target cancer cells specifically, but also release drugs in a photocontrollable manner. We demonstrated the potential of automated and modular ApDC technology for applications in targeted cancer therapy.
Subject Area有机化学
DOI10.1021/ja4117395
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Cited Times:72[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39154
Collection上海有机化学研究所
Corresponding AuthorTan YH(谭蔚泓)
Affiliation1.湖南大学
2.中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Wang RW,ZHU GUIZHI,MEI LEI,et al. Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery[J]. J. Am. Chem. Soc.,2014,136(7):2731-2734.
APA 王若文.,ZHU GUIZHI.,MEI LEI.,XIE YAN.,MA HAIBIN.,...&谭蔚泓.(2014).Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery.J. Am. Chem. Soc.,136(7),2731-2734.
MLA 王若文,et al."Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery".J. Am. Chem. Soc. 136.7(2014):2731-2734.
Files in This Item:
File Name/Size DocType Version Access License
2014100.pdf(919KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[王若文]'s Articles
[ZHU GUIZHI]'s Articles
[MEI LEI]'s Articles
Baidu academic
Similar articles in Baidu academic
[王若文]'s Articles
[ZHU GUIZHI]'s Articles
[MEI LEI]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[王若文]'s Articles
[ZHU GUIZHI]'s Articles
[MEI LEI]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.