中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 上海有机化学研究所  > 期刊论文
学科主题: 有机化学
题名: Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery
其他题名: 为靶向药物传递的适体偶联药物的自动模块化合成
作者: Wang RW(王若文)1; ZHU GUIZHI1; MEI LEI1; XIE YAN1; MA HAIBIN1; YE MAO1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
通讯作者: 谭蔚泓
刊名: J. Am. Chem. Soc.
发表日期: 2014
DOI: 10.1021/ja4117395
卷: 136, 期:7, 页:2731-2734
收录类别: SCI
英文摘要: Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis, which is a phosphoramdite containing an anticancer drug moiety and a photocleavable linker. Using this module, we have realized automated and modular synthesis of ApDCs, and multiple drugs were efficiently incorporated into ApDCs at predesigned positions. The ApDCs not only recognize target cancer cells specifically, but also release drugs in a photocontrollable manner. We demonstrated the potential of automated and modular ApDC technology for applications in targeted cancer therapy.
语种: 英语
相关网址: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39154
Appears in Collections:上海有机化学研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2014100.pdf(919KB)期刊论文作者接受稿开放获取View Download

作者单位: 1.湖南大学
2.中科院上海有机化学研究所

Recommended Citation:
Wang RW,ZHU GUIZHI,MEI LEI,et al. Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery[J]. J. Am. Chem. Soc.,2014,136(7):2731-2734.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王若文]'s Articles
[ZHU GUIZHI]'s Articles
[MEI LEI]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王若文]‘s Articles
[ZHU GUIZHI]‘s Articles
[MEI LEI]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2014100.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace