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Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery
其他题名为靶向药物传递的适体偶联药物的自动模块化合成
Wang RW(王若文)1; ZHU GUIZHI1; MEI LEI1; XIE YAN1; MA HAIBIN1; YE MAO1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
2014
发表期刊J. Am. Chem. Soc.
卷号136期号:7页码:2731-2734
摘要Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis, which is a phosphoramdite containing an anticancer drug moiety and a photocleavable linker. Using this module, we have realized automated and modular synthesis of ApDCs, and multiple drugs were efficiently incorporated into ApDCs at predesigned positions. The ApDCs not only recognize target cancer cells specifically, but also release drugs in a photocontrollable manner. We demonstrated the potential of automated and modular ApDC technology for applications in targeted cancer therapy.
学科领域有机化学
DOI10.1021/ja4117395
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收录类别SCI
语种英语
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被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39154
专题上海有机化学研究所
通讯作者Tan YH(谭蔚泓)
作者单位1.湖南大学
2.中科院上海有机化学研究所
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GB/T 7714
Wang RW,ZHU GUIZHI,MEI LEI,et al. Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery[J]. J. Am. Chem. Soc.,2014,136(7):2731-2734.
APA 王若文.,ZHU GUIZHI.,MEI LEI.,XIE YAN.,MA HAIBIN.,...&谭蔚泓.(2014).Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery.J. Am. Chem. Soc.,136(7),2731-2734.
MLA 王若文,et al."Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery".J. Am. Chem. Soc. 136.7(2014):2731-2734.
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