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Chiral- Amine- Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives
Alternative Title手性胺催化的色胺衍生物的不对称溴环化
Cai Q(蔡泉); Yin Q(殷勤); You SL(游书力)
Source PublicationAsian J. Org. Chem.
AbstractChiral hexahydropyrro[2,3]indole (HPI) units exist widely in natural and unnatural products with significant biological activities. The enantioselective synthesis of brominated hexahydropyrrolo[2,3-b]indole (HPI) subunits by asymmetric bromocyclization of tryptamine derivatives catalyzed by a chiral amine has been realized. In the presence of hydroquinine 1,4-phthalazinediyl diether ((DHQ)(2)PHAL, 20mol%) and L-(-)-camphorsulfonic acid (20mol%), enantioenriched brominated HPI derivatives were obtained from readily available substituted tryptamines in up to 99% yield and 73%ee.
Subject Area金属有机化学
Indexed BySCI
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Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYou SL(游书力)
Recommended Citation
GB/T 7714
Cai Q,Yin Q,You SL. Chiral- Amine- Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives[J]. Asian J. Org. Chem.,2014,3(4):408-411.
APA 蔡泉,殷勤,&游书力.(2014).Chiral- Amine- Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives.Asian J. Org. Chem.,3(4),408-411.
MLA 蔡泉,et al."Chiral- Amine- Catalyzed Asymmetric Bromocyclization of Tryptamine Derivatives".Asian J. Org. Chem. 3.4(2014):408-411.
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