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学科主题: 金属有机化学
题名: Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates
其他题名: 不对称有机催化合成双吲哚哌啶羧酸酯
作者: ZHONG SABILLA1; NIEGER MARTIN1; BIHLMEIER ANGELA1; Shi M(施敏)1; BRAESE STEFAN1
通讯作者: 施敏 ; BRAESE STEFAN
刊名: Org. Biomol. Chem.
发表日期: 2014
DOI: 10.1039/c4ob00234b
卷: 12, 期:20, 页:3265-3270
收录类别: SCI
英文摘要: We developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synthesized in up to 70% yield and 99% ee, and they were experimentally and computationally analyzed regarding their relative and absolute stereochemistry.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39056
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.德国KIT有机化学研究所
3.芬兰赫尔辛基大学
4.德国KIT物理化学研究所

Recommended Citation:
ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,et al. Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates[J]. Org. Biomol. Chem.,2014,12(20):3265-3270.
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