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Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates
Alternative Title不对称有机催化合成双吲哚哌啶羧酸酯
ZHONG SABILLA1; NIEGER MARTIN1; BIHLMEIER ANGELA1; Shi M(施敏)1; BRAESE STEFAN1
2014
Source PublicationOrg. Biomol. Chem.
Volume12Issue:20Pages:3265-3270
AbstractWe developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synthesized in up to 70% yield and 99% ee, and they were experimentally and computationally analyzed regarding their relative and absolute stereochemistry.
Subject Area金属有机化学
DOI10.1039/c4ob00234b
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Indexed BySCI
Language英语
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39056
Collection金属有机化学国家重点实验室
Corresponding AuthorShi M(施敏); BRAESE STEFAN
Affiliation1.中科院上海有机化学研究所
2.德国KIT有机化学研究所
3.芬兰赫尔辛基大学
4.德国KIT物理化学研究所
Recommended Citation
GB/T 7714
ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,et al. Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates[J]. Org. Biomol. Chem.,2014,12(20):3265-3270.
APA ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,施敏,&BRAESE STEFAN.(2014).Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates.Org. Biomol. Chem.,12(20),3265-3270.
MLA ZHONG SABILLA,et al."Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates".Org. Biomol. Chem. 12.20(2014):3265-3270.
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