Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates

doi:10.1039/c4ob00234b

	Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates
其他题名	不对称有机催化合成双吲哚哌啶羧酸酯
	ZHONG SABILLA 1; NIEGER MARTIN 1; BIHLMEIER ANGELA 1; Shi M(施敏)1; BRAESE STEFAN 1
	2014
发表期刊	Org. Biomol. Chem.
卷号	12 期号:20 页码:3265-3270
摘要	We developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synthesized in up to 70% yield and 99% ee, and they were experimentally and computationally analyzed regarding their relative and absolute stereochemistry.
学科领域	金属有机化学
DOI	10.1039/c4ob00234b
URL	查看原文
收录类别	SCI
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.sioc.ac.cn/handle/331003/39056
专题	金属有机化学国家重点实验室
通讯作者	Shi M(施敏); BRAESE STEFAN
作者单位	1.中科院上海有机化学研究所 2.德国KIT有机化学研究所 3.芬兰赫尔辛基大学 4.德国KIT物理化学研究所
推荐引用方式 GB/T 7714	ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,et al. Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates[J]. Org. Biomol. Chem.,2014,12(20):3265-3270.
APA	ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,施敏,&BRAESE STEFAN.(2014).Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates.Org. Biomol. Chem.,12(20),3265-3270.
MLA	ZHONG SABILLA,et al."Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates".Org. Biomol. Chem. 12.20(2014):3265-3270.

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