| Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates | |
| Alternative Title | 不对称有机催化合成双吲哚哌啶羧酸酯 |
| ZHONG SABILLA1; NIEGER MARTIN1; BIHLMEIER ANGELA1; Shi M(施敏)1; BRAESE STEFAN1 | |
| 2014 | |
| Source Publication | Org. Biomol. Chem.
 |
| Volume | 12Issue:20Pages:3265-3270 |
| Abstract | We developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synthesized in up to 70% yield and 99% ee, and they were experimentally and computationally analyzed regarding their relative and absolute stereochemistry. |
| Subject Area | 金属有机化学 |
| DOI | 10.1039/c4ob00234b |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sioc.ac.cn/handle/331003/39056 |
| Collection | 金属有机化学国家重点实验室 |
| Corresponding Author | Shi M(施敏); BRAESE STEFAN |
| Affiliation | 1.中科院上海有机化学研究所 2.德国KIT有机化学研究所 3.芬兰赫尔辛基大学 4.德国KIT物理化学研究所 |
| Recommended Citation GB/T 7714 | ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,et al. Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates[J]. Org. Biomol. Chem.,2014,12(20):3265-3270. |
| APA | ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,施敏,&BRAESE STEFAN.(2014).Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates.Org. Biomol. Chem.,12(20),3265-3270. |
| MLA | ZHONG SABILLA,et al."Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates".Org. Biomol. Chem. 12.20(2014):3265-3270. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2014211.pdf（967KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | Application Full Text | |
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